Topic
Cyclase
About: Cyclase is a research topic. Over the lifetime, 10162 publications have been published within this topic receiving 388566 citations.
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TL;DR: VIP was markedly less potent and less efficient on this enzyme than PACAP, this activation being compatible with the occupancy of specific high affinity PACAP receptor.
118 citations
TL;DR: The following conclusions can be drawn: (i) catecholamines, in the presence of a guanine nucleotide, stimulate the exchange of bound and exogenous nucleotide; (ii) the exchange reaction is involved in both the activation of adenylate cyclase and in the reciprocal effects of hormone and guanines nucleotides on each other's binding.
118 citations
118 citations
TL;DR: The limited response obtained in DCT as well as the clearcut effect elicited by AVP in MAL (the functioning of which is not known to be controlled by ADH) were unexpected observations; their possible physiological implications will be discussed.
Abstract: AVP dependent adenylate cyclase activity was measured in single pieces of 8 different tubular segments isolated from collagenase treated rabbit kidneys.
118 citations
TL;DR: A strong positive correlation between the magnitude of adenylate cyclase stimulation and the summated electrical response of the olfactory epithelium (electro-olfactogram) evoked by individual odorants is reported.
Abstract: An odor-stimulated adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] is thought to mediate olfactory transduction in vertebrates. However, it is not known whether the adenylate cyclase serves this function for all odorants or for only certain classes of odorants. To investigate this question, we have compared the abilities of 35 odorants to stimulate the adenylate cyclase and to elicit an electrophysiological response. We report a strong positive correlation between the magnitude of adenylate cyclase stimulation and the summated electrical response of the olfactory epithelium (electro-olfactogram) evoked by individual odorants. We also show that the adenylate cyclase stimulator forskolin equally attenuates the electro-olfactogram response for all odorants tested. These data provide evidence that the adenylate cyclase mediates transduction for a wide variety of odorants.
118 citations