Topic
Cyclase
About: Cyclase is a research topic. Over the lifetime, 10162 publications have been published within this topic receiving 388566 citations.
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Journal Article•
403 citations
TL;DR: Results show that the bicarbonate-sensitive adenylate cyclase system regulates sperm motility and suggest that this system is common to all mammals.
403 citations
TL;DR: The results suggest that the physiological effects of dopamine in the ganglion, and possibly elsewhere in the nervous system, may be mediated by stimulating the synthesis of adenosine 3',5'-monophosphate.
Abstract: An adenyl cyclase activated by low concentrations of dopamine has been found in the mammalian superior cervical sympathetic ganglion The existence of this enzyme may account for the increased amount of adenosine 3',5' monophosphate associated with synaptic activity in the ganglion The results suggest that the physiological effects of dopamine in the ganglion, and possibly elsewhere in the nervous system, may be mediated by stimulating the synthesis of adenosine 3',5'-monophosphate
396 citations
TL;DR: The apparent ability of ARF to bind to the alpha subunit of Gs suggests that it may play another, unknown role in the regulation of adenylate cyclase activity.
392 citations
TL;DR: The conclusion is that the sole site of IAP action is the guanine nucleotide regulatory protein (Ni) that is required for transmission of inhibitory signals from receptors to the catalytic unit of adenylate cyclase; the function of Ni is lost upon IAP-catalyzed ADP ribosylation of the Mr = 41,000 protein which appears to be an active subunit of Ni.
386 citations