Topic
Cyclase
About: Cyclase is a research topic. Over the lifetime, 10162 publications have been published within this topic receiving 388566 citations.
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TL;DR: Observations indicated that these hormones increased heart adenyl cyclase activity by different mechanisms and could be blocked by beta-adrenergic blocking agents.
95 citations
TL;DR: Regression analysis shows a linear correlation between the percentage of adenyl-cyclase stimulation and the magnitude of changes of net water and sodium flux and this data strongly support the hypothesis thatadenyl cyclase is the mediator of the accumulation of intestinal fluid in cholera.
Abstract: Recent evidence suggests that the diarrheal effect of cholera enterotoxin is mediated by stimulation of intestinal adenyl cyclase and increased formation of intracellular adenosine 3' , 5' -cyclic monophosphate (cyclic AMP) This study demonstrates the stimulation of adenyl cyclase in canine jejunal mucosa by cholera toxin during experimental cholera Percentage increase of basal adenyl-cyclase activity correlates in time course and magnitude with simultaneously measured changes of net water and sodium fluxes Onset of enzyme activation and change of net water and sodium fluxes occur simultaneously between 30 and 60 min Maximal changes in activity of the enzyme and net movement of water and sodium also coincide at 150 and 180 min By 48 hr, the restoration of normal fluxes is accompanied by the return of enzymatic activity to baseline value Regression analysis shows a linear correlation between the percentage of adenyl-cyclase stimulation and the magnitude of changes of net water and sodium flux These data strongly support the hypothesis that adenyl cyclase is the mediator of the accumulation of intestinal fluid in cholera
95 citations
TL;DR: It is suggested that both the catecholamine-stimulated GTPase and the binding of the guanyl nucleotides which activate the adenylate cyclase take place at the same regulatory site.
95 citations
TL;DR: The decreased responsiveness to catecholamines seen in aging man may be due, in some tissues, to reduced adenylate cyclase activity, specifically, the catalytic unit of the enzyme complex.
Abstract: Lymphocyte adenylate cylase activity is reduced in aging man, despite unaltered beta-adrenergic receptor characteristics To define the component of human lymphocyte adenylate cyclase which is reduced in aging, we assessed nucleotide-regulatory protein (N-protein) function by complementation of eye- S49 mouse lymphoma cells and catalytic unit activity by forskolin stimulation Within the enzyme complex, N-protein function is unchanged, while catalytic unit activity is 36 fold greater in young than elderly The decreased responsiveness to catecholamines seen in aging man may be due, in some tissues, to reduced adenylate cyclase activity, specifically, the catalytic unit of the enzyme complex
95 citations
TL;DR: Examination of components of the cAMP system in primary cultures of differentiating chick myoblasts revealed a basal intracellular cAMP level of 50–100 pmole/mg of DNA, which increased ten to fifteen-fold for approximately 1 hr between 37.5 and 39.5 hr of culture, only 5–6 hr before the initiation of myoblast fusion.
94 citations