Topic
Cyclase
About: Cyclase is a research topic. Over the lifetime, 10162 publications have been published within this topic receiving 388566 citations.
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TL;DR: The possibility that the dopamine-inhibited enzyme is located in mammotrophs appears supported by its observation in the female rat pituitary, which contains this type of cells in much larger proportion than the male gland.
92 citations
TL;DR: These caffeine analogs have an A1/A2 selectivity ratio of about 10-20 and are the first selective A2 receptor antagonists yet reported and may provide the basis for the further development of highly potent and highly selective A 2 adenosine receptor antagonists.
92 citations
TL;DR: In Escherichia coli, the cya locus of B. pertussis is reconstructed by cloning the different genes on appropriate vectors under the control of strong promoters and E. coli-specific translation initiation signals to elucidate both the mechanism and the structural requirements of holotoxin activation.
92 citations
Journal Article•
TL;DR: Evidence is provided supporting the presence of a GABAB receptor in the cerebellar granule cells and it is suggested that this receptor couples with the guanine nucleotide inhibitory unit to inhibit the formation of cyclic AMP.
Abstract: In primary cultures of cerebellar granule cells, the gamma aminobutyric acid B (GABAB) receptor couples to an inhibitory mechanism of adenylate cyclase. The inhibition of adenylate cyclase can be observed either by the measurement of cellular cyclic AMP content or by in vitro measurement of adenylate cyclase from plasma membrane of these cerebellar granule cells. The GABAB receptors can be stimulated by GABA and the GABA analog, baclofen. This receptor-mediated inhibition of adenylate cyclase was blocked by the pertussis toxin, islet-activating protein. Furthermore, the authors show that islet-activating protein catalyzed the ADP ribosylation of the guanine nucleotide inhibitory unit (MW 41,000) in the cerebellar granule cells. In summary, the authors provide evidence supporting the presence of a GABAB receptor in the cerebellar granule cells and suggest that this receptor couples with the guanine nucleotide inhibitory unit to inhibit the formation of cyclic AMP.
92 citations
TL;DR: The inhibitory action of putative "purinergic" neurotransmitters is postulated to be due to their effects on adenylate cyclase activity, which appears to be noncooperative in mouse neuroblastoma NS20 cells.
92 citations