Topic
Cyclase
About: Cyclase is a research topic. Over the lifetime, 10162 publications have been published within this topic receiving 388566 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: The S49 mouse lymphoma cell line is used to study the increase and subsequent decrease in cyclic AMP levels (termed refractoriness) following incubation of cells with isoproterenol, and suggests that adenylate cyclase may exert regulatory controls on beta-adrenergic receptors in addition to generation of cyclicAMP.
203 citations
TL;DR: The mutated residues that comprise the core of the dimerization interface and the ability of these mutants to dimerize and to bind and activate the MCP-1 receptor, CCR2b, suggest that M CP-1 binds and activates its receptor as a monomer.
202 citations
TL;DR: The localization of multiple binding sites in the crude synaptosomal fraction correlates well with the localization of dopamine-sensitive adenylate cyclase in this fraction.
201 citations
TL;DR: It is proposed that PA interacts with its own specific membrane receptors, thereby triggering multiple effector systems in 3T3 cells, and mediated by an islet-activating protein substrate GTP-binding protein.
201 citations
TL;DR: It is reported here that the toxin also catalyzes ADP-ribosylation of the alpha-subunit of transducin in ROS membranes, which indicates close functional homology between trans Ducin of ROS and the N protein of adenylate cyclase.
201 citations