Topic
Cytology
About: Cytology is a research topic. Over the lifetime, 7177 publications have been published within this topic receiving 132705 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: LSIL cytology is best managed by colposcopy initially, because there was no useful triage strategy identified, and at lower cytology thresholds, sensitivity would improve but would ultimately yield unacceptably high referral rates.
350 citations
TL;DR: Cytobrush cytology was the most reliable method of diagnosing endometritis in cattle and was chosen as the reference diagnostic test.
343 citations
TL;DR: Endobiliary sampling is technically difficult and has a limited sensitivity for the diagnosis of malignant biliary stenosis and should be combined with cytology to increase the sensitivity.
341 citations
TL;DR: Anal cytology may be a useful screening tool to detect ASIL, particularly in HIV-positive men, and anal cytology should be used in conjunction with histopathologic confirmation.
Abstract: Anal squamous intraepithelial lesions (ASIL) are common in homosexual and bisexual men, and high-grade ASIL (HSIL) in particular may represent an anal cancer precursor. Cervical cytology is a useful screening tool for detection of cervical HSIL to prevent cervical cancer. To assess anal cytology as a screening tool for anal disease, we compared anal cytology with anoscopy and histopathology of anal biopsies. A total of 2958 anal examinations were performed on 407 HIV-positive and 251 HIV-negative homosexual or bisexual men participating in a prospective study of ASIL. The examination consisted of a swab for anal cytology and anoscopy with 3% acetic acid and biopsy of visible lesions. Defining abnormal cytology as including atypical squamous cells of undetermined significance and ASIL, the sensitivity of anal cytology for detection of biopsy-proven ASIL was 69% (95% confidence interval: 60 to 78) in HIV-positive and 47% (95% confidence interval; 26 to 68) in HIV-negative men at their first visit and was 81% and 50%, respectively, for all subsequent visits combined. The absence of columnar cells did not affect the sensitivity, specificity, or predictive value of anal cytology. Anal cytology may be a useful screening tool to detect ASIL, particularly in HIV-positive men. The grade of disease on anal cytology did not always correspond to the histologic grade, and anal cytology should be used in conjunction with histopathologic confirmation.
331 citations