Topic
Cytotoxic T cell
About: Cytotoxic T cell is a research topic. Over the lifetime, 92492 publications have been published within this topic receiving 4768477 citations. The topic is also known as: killer T cell & cytotoxic T lymphocyte.
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TL;DR: In this paper, the authors examined the molecular interactions required for peripheral CD8+ T cell expansion in lymphopenic mice without conventional antigenic stimulation and found that the expansion of T cells in lymph openic hosts was peptide specific.
557 citations
TL;DR: The influenza A virus M 2 protein is expressed abundantly at the cell surface, and in addition to the hemagglutinin (HA) and neuraminidase (NA), is a third virus-specific membrane protein this paper.
557 citations
TL;DR: It is concluded that Stat5a/b have an essential, nonredundant role in regulating Treg cells, and that Stat3 and Stat5 a/b appear to have opposing roles in the regulation of Foxp3.
556 citations
TL;DR: Lymphocyte isolation fails to recover most cells and biases against certain subsets, residents greatly outnumber recirculating cells within non-lymphoid tissues, and memory subset homing to inflammation does not conform to previously hypothesized migration patterns.
556 citations
TL;DR: In the presence of antigen presenting cells, a murine T helper cell specific for murine hemoglobin responded to its immunogenic peptide by both cytokine (interleukin-4) secretion and proliferation and an altered peptide with a single amino acid substitution induced only cytokine secretion and did not induce proliferation.
Abstract: In the presence of antigen presenting cells, a murine T helper (Th) cell specific for murine hemoglobin (Hb) responded to its immunogenic peptide by both cytokine (interleukin-4) secretion and proliferation. An altered Hb peptide with a single amino acid substitution induced only cytokine secretion and did not induce proliferation. Interleukin-1 costimulated and restored the Th proliferative response to normal levels. The altered peptide also supported cognate T cell-B cell interactions indicative of T cell helper function. Thus, this result suggests that the T cell receptor has the capacity of differential signaling.
556 citations