scispace - formally typeset
Search or ask a question
Topic

Dengue fever

About: Dengue fever is a research topic. Over the lifetime, 17463 publications have been published within this topic receiving 485745 citations. The topic is also known as: Dengue & dengue disease.


Papers
More filters
Journal ArticleDOI
TL;DR: Clinical profile of patients with dengue virus infection hospitalized at a single center during the first outbreak of denge in Makkah, Saudi Arabia from April to July 2004 is described.

152 citations

Journal ArticleDOI
TL;DR: The results obtained demonstrate that adults with a primary dengue infection are at risk of developing the severe disease (DHF) if they are infected with a different serotype.

152 citations

Journal ArticleDOI
TL;DR: The age of highest incidence has increased, and the age group most severely affected is now those 5–9 years old, so the case fatality rate has decreased with improved treatment and is now only 0·28%.
Abstract: Dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) are reportable diseases, the third most common causes for hospitalization of children in Thailand. Data collected from the Ministry of Public Health were analysed for trends. Rates of DHF increased in Thailand until 1987 when the largest epidemic ever, 325/100000 population, was recorded. Whereas the disease used to be confined to large cities, the rate is now higher in rural (102.2 per 100000) than urban areas (95.4 per 100000 in 1997). The age of highest incidence has increased, and the age group most severely affected is now those 5-9 years old (679/100000 in 1997). The case fatality rate has decreased with improved treatment and is now only 0.28%.

152 citations

Journal ArticleDOI
TL;DR: Testing the hypothesis that body size alters the susceptibility of Aedes aegypti and Aedes albopictus mosquitoes to dengue virus infection and subsequent dissemination throughout the body of the mosquito found smaller-sized females were significantly more likely to become infected and to disseminate virus than larger individuals.
Abstract: The size of arthropod vectors may affect their ability to transmit pathogens. Here we test the hypothesis that body size alters the susceptibility of Aedes aegypti and Aedes albopictus mosquitoes to dengue virus (DENV) infection and subsequent dissemination throughout the body of the mosquito. After feeding on blood containing known quantities of virus, smaller-sized females were significantly more likely to become infected and to disseminate virus than larger individuals. The effects of size were stronger for Ae. aegypti and independent of rearing conditions. Ae. albopictus was more susceptible to DENV infection and had higher virus titer in the body than Ae. aegypti, yet infected Ae. aegypti disseminated DENV more readily than infected Ae. albopictus. These results are consistent with the concept that Ae. aegypti is a more competent vector of DENV and emphasize the importance of body size in determining adult infection parameters.

152 citations

Journal Article
TL;DR: The duration of illness and prolonged symptom duration in 9% of the subjects indicate that the burden of dengue illness is substantially different from other non-dengue febrile illness in the study cohort, and highlights the paucity of early prognostic markers for d Dengue fever in adults.
Abstract: Introduction: Dengue is a major public health problem in Singapore Age-specific dengue morbidity rates are highest in the young adult population, unlike in many other Southeast Asian countries where dengue is mainly a paediatric disease Hence, the World Health Organization (WHO) guidelines on dengue diagnosis and management which were developed using the paediatric experiences, may not be suitable for the management of adult dengue infections Materials and Methods: The Early DENgue (EDEN) infection and outcome study is a collabo- rative longitudinal study to investigate epidemiological, clinical, viral and host-specific features of early dengue-infected adults, in an effort to identify new early markers for prognostication Patients presenting with early undifferentiated fever were included in the study We carried out an interim analysis to look for early indicators of severe disease Results: During the period of this interim study analysis, 455 febrile patients were recruited Of these, 133 were confirmed as acute dengue cases based on dengue-specific polymerase chain reaction (PCR) results There were significant clinical and epidemiological differences between dengue and febrile non-dengue cases Nine per cent of the dengue cases experienced persistent tiredness, drowsiness and loss of appetite beyond 3 weeks of illness Quantitation of viral loads using the crossover (Ct) value of real-time RT-PCR correlated with the duration of symptoms More than half of both primary and secondary dengue cases were hospitalised There was no dengue-related mortality in this study Conclusion: The duration of illness and prolonged symptom duration in 9% of the subjects indicate that the burden of dengue illness is substantially different from other non-dengue febrile illness in our study cohort Our study also highlights the paucity of early prognostic markers for dengue fever in adults Ann Acad Med Singapore 2006;35:783-9

151 citations


Network Information
Related Topics (5)
Malaria
37K papers, 914K citations
88% related
Vaccination
65.1K papers, 1.7M citations
81% related
Virus
136.9K papers, 5.2M citations
80% related
Drug resistance
28.4K papers, 1.1M citations
80% related
Viral load
26.7K papers, 1M citations
79% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20241
20231,464
20222,917
2021992
20201,237
20191,168