Topic
Dengue fever
About: Dengue fever is a research topic. Over the lifetime, 17463 publications have been published within this topic receiving 485745 citations. The topic is also known as: Dengue & dengue disease.
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TL;DR: While it is not possible to avoid dengue in areas infested with A. aegypti, it is possible to prevent major epidemics by improving epidemiological surveillance, and it is both possible and feasible to reduce the disease's case fatality from the current 5 to 6% to some 1% in the severe forms.
Abstract: Dengue is now the main reemerging disease in the world. In the absence of an efficacious preventive vaccine and effective etiologic treatment and chemoprophylaxis, the only vulnerable link for reducing dengue transmission is the mosquito Aedes aegypti, its principal vector. There are many difficulties in combating this mosquito in large and medium-sized cities. The complexity of contemporary urban life generates factors that facilitate the mosquito's proliferation and constraints on the reduction of its infestation rates. The objectives of dengue control should be based on available scientific and technical knowledge. Thus, while it is not possible to avoid dengue in areas infested with A. aegypti, it is possible to prevent major epidemics by improving epidemiological surveillance, and it is both possible and feasible to reduce the disease's case fatality from the current 5 to 6% to some 1% in the severe forms. The elaboration and execution of strategic plans for the organization of medical care for suspected dengue cases have proven to be a highly useful instrument to reduce case fatality both in other countries and in some cities of Brazil.
210 citations
TL;DR: Findings suggest that hepatocytes are the major sites of DEN virus replication in the liver and that DEN virus induces apoptosis of hepatocytes in vivo.
209 citations
TL;DR: It is understood that the process is initiated by infection with a virulent d Dengue virus, often in the presence of antibodies that enhance dengue virus infection in secondary infection, and then triggered by rapidly elevated cytokines and chemical mediators that were produced by intense immune activation.
Abstract: Dengue virus infections are a serious cause of morbidity and mortality in most tropical and subtropical areas of the world; Southeast and South Asia, Central and South America, and the Caribbean. Dengue virus infection can be asymptomatic or causes two forms of illness, dengue fever (DF) and dengue hemorrhagic fever (DHF), which is the severe form of dengue illness and often fatal. Pathogenesis of DHF has been analyzed, and two mechanisms are considered to be responsible. These include dengue serotype cross-reactive immune responses and virulence of the virus. The immunopathological mechanisms include a complex series of immune responses. Rapid increase in the levels of cytokines, especially TNF-alpha, and chemical mediators play a key role in inducing unique clinical manifestations of DHF such as plasma leakage, shock, and hemorrhagic manifestations. It is understood that the process is initiated by infection with a virulent dengue virus, often in the presence of antibodies that enhance dengue virus infection in secondary infection, and then triggered by rapidly elevated cytokines and chemical mediators that were produced by intense immune activation. However, complete understanding of the entire pathological mechanism is far from complete, and further studies are still needed.
208 citations
TL;DR: Describing the isolation of a neutralizing antibody from a DENV1-infected patient and demonstrating that the antibody binds across two adjacent viral envelope proteins and identifying the amino acids that comprise the binding site provide a structural and molecular context for durable, serotype-specific immunity to DENV infection.
Abstract: Dengue virus (DENV) is a mosquito-borne flavivirus that affects 2.5 billion people worldwide. There are four dengue serotypes (DENV1 to DENV4), and infection with one elicits lifelong immunity to that serotype but offers only transient protection against the other serotypes. Identification of the protective determinants of the human antibody response to DENV is a vital requirement for the design and evaluation of future preventative therapies and treatments. Here, we describe the isolation of a neutralizing antibody from a DENV1-infected patient. The human antibody 14c10 (HM14c10) binds specifically to DENV1. HM14c10 neutralizes the virus principally by blocking virus attachment; at higher concentrations, a post-attachment step can also be inhibited. In vivo studies show that the HM14c10 antibody has antiviral activity at picomolar concentrations. A 7 A resolution cryoelectron microscopy map of Fab fragments of HM14c10 in a complex with DENV1 shows targeting of a discontinuous epitope that spans the adjacent surface of envelope protein dimers. As found previously, a human antibody specific for the related West Nile virus binds to a similar quaternary structure, suggesting that this could be an immunodominant epitope. These findings provide a structural and molecular context for durable, serotype-specific immunity to DENV infection.
208 citations
TL;DR: Dengue is no longer confined to the tropics and is a global disease; outcomes can be optimized by early recognition and cautious titrated fluid replacement, especially in resource-limited environments.
Abstract: Objectives:To provide a comprehensive review of dengue, with an emphasis on clinical syndromes, classification, diagnosis, and management, and to outline relevant aspects of epidemiology, immunopathogenesis, and prevention strategies. Dengue, a leading cause of childhood mortality in Asia and South
208 citations