Dengue virus

About: Dengue virus is a research topic. Over the lifetime, 12671 publications have been published within this topic receiving 461406 citations. The topic is also known as: DENV.

A simple technique for demonstrating transmission of dengue virus by mosquitoes without the use of vertebrate hosts.

Abstract: Aedes albopictus mosquitoes infected with dengue type 2 virus transmitted virus to measured small amounts of fluid which could be titrated readily for virus content. It was found that the percentage of mosquitoes transmitting was related to the extent of salivary gland infection. It was not uncommon for mosquitoes to transmit as much as 104 mosquito infectious doses50 of virus and transmission of significant amounts of virus was observed even though an insect only probed the test suspension without feeding to repletion. Transmission of virus was demonstrated as early as 10 days after oral infection when mosquitoes were held at 32° C.

Seroepidemiology of dengue virus infection among adults in Singapore.

Abstract: Introduction: To determine the seroepidemiology of dengue virus infection in a representative sample of the adult resident population aged 18 years old to 74 years old in Singapore and to estimate the proportion of asymptomatic dengue infection during the 2004 epidemic. Materials and Methods: The study was based on 4152 stored blood samples collected between September and December 2004 from participants aged 18 years old to 74 years old during the 2004 National Health Survey. Sera were tested for IgG and IgM antibodies using a commercial test kit (PanBio Capture/Indirect ELISA). Results: Of the study population, 59.0% and 2.6% tested positive for dengue IgG (past infection) and IgM/high-titre IgG (recent infection), respectively. Only 17.2% of young adults aged 18 years old to 24 years old were dengue IgG positive. Multivariate analyses showed that older age, Indian ethnicity and male gender were signifi cantly associated with past infection, whereas only age was signifi cantly associated with recent dengue infection. Based on the dengue cases notifi ed during the period of survey, it was estimated that for every 23 individuals recently infected with dengue, only 1 was reported to the health authority as a clinical case. Conclusion: The Singapore population is highly susceptible to dengue epidemics despite its aggressive Aedes prevention and control programme. The fi nding of a high proportion of unreported cases due to asymptomatic and subclinical infection poses a challenge for dengue control. Ann Acad Med Singapore 2009;38:667-75

Dengue: A Minireview.

Abstract: Dengue, caused by infection of any of four dengue virus serotypes (DENV-1 to DENV-4), is a mosquito-borne disease of major public health concern associated with significant morbidity, mortality, and economic cost, particularly in developing countries. Dengue incidence has increased 30-fold in the last 50 years and over 50% of the world’s population, in more than 100 countries, live in areas at risk of DENV infection. We reviews DENV biology, epidemiology, transmission dynamics including circulating serotypes and genotypes, the immune response, the pathogenesis of the disease as well as updated diagnostic methods, treatments, vector control and vaccine developments.

Autochthonous Dengue Fever, Tokyo, Japan, 2014

Abstract: After 70 years with no confirmed autochthonous cases of dengue fever in Japan, 19 cases were reported during August–September 2014. Dengue virus serotype 1 was detected in 18 patients. Phylogenetic analysis of the envelope protein genome sequence from 3 patients revealed 100% identity with the strain from the first patient (2014) in Japan.