Depression (differential diagnoses)

About: Depression (differential diagnoses) is a research topic. Over the lifetime, 56557 publications have been published within this topic receiving 2048357 citations.

The Experience of Symptoms of Depression in Men vs Women: Analysis of the National Comorbidity Survey Replication

Abstract: RESULTS Men reported higher rates of anger attacks/aggression, substance abuse, and risk taking compared with women. Analyses using the scale that included alternative, male-type symptoms of depression found that a higher proportion of men (26.3%) than women (21.9%) (P = .007) met criteria for depression. Analyses using the scale that included alternative and traditional depression symptoms found that men and women met criteria for depression in equal proportions: 30.6% of men and 33.3% of women (P =. 57).

Prospective study on the relationship between depressive symptoms and chronic musculoskeletal pain.

Abstract: Chronic pain and depression often coexist, but there is still uncertainty about the nature of this relationship. Virtually all the available data are cross-sectional and therefore do not clarify the causal relationship between the two variables. In epidemiological studies, chronic pain has often been defined fairly liberally in terms of the actual duration. In this study, the definition of chronic pain was based upon self-reports of pain present for most of the days in at least 1 month of the 12 months preceding the interview. We tested the hypotheses that depression causes pain and that pain causes depression in a sample of 2324 subjects who were assessed for the presence of musculo-skeletal pain and the presence of depression, using for the latter a standardized published instrument called the Center for Epidemiologic Studies Depression scale (CES-D). The subjects were first examined using the National Health and Nutrition Survey (NHANES 1) of the United States National Center for Health Statistics from 1974 to 1975, and were followed-up from 1981 to 1984. Those with data on both occasions represent 76% of an initial population of 3059 persons. On logistic regression analysis depressive symptoms at year 1 significantly predicted the development of chronic musculo-skeletal pain at year 8 with an odds ratio of 2.14 for the depressed subjects compared with the non-depressed subjects. In patients in whom pain was present at baseline no socio-demographic variable alone predicted its persistence; however, male sex and white race together with 2 items of the CES-D did predict the persistence of existing pain.(ABSTRACT TRUNCATED AT 250 WORDS)

The efficacy of cognitive therapy in depression: a treatment trial using cognitive therapy and pharmacotherapy, each alone and in combination.

Abstract: We report an extensive study which compares cognitive therapy, antidepressant drugs and a combination of these two, in depressed patients seen either in general practice or an out-patient department. One-hundred and forty patients were screened for primary major depression and 64 patients completed the trial. All were rated on seven measures of mood, including independent observer-rated and self-rated depression and scales of anxiety and irritability. Patients were randomly assigned to cognitive therapy, antidepressants or a combination of the two. The antidepressant drug group did less well in both hospital and general practice and combination treatment was superior to drug treatment in both hospital and general practice. In general practice, cognitive therapy was superior to drug treatment. The presence of endogenous features did not affect response to treatment. The results are discussed in terms of Beck's cognitive theory of depression and factors of presumed causal importance of depression in general practice.

Treatment-resistant depression: therapeutic trends, challenges, and future directions.

Abstract: Background Patients with major depression respond to antidepressant treatment, but 10%-30% of them do not improve or show a partial response coupled with functional impairment, poor quality of life, suicide ideation and attempts, self-injurious behavior, and a high relapse rate. The aim of this paper is to review the therapeutic options for treating resistant major depressive disorder, as well as evaluating further therapeutic options. Methods In addition to Google Scholar and Quertle searches, a PubMed search using key words was conducted, and relevant articles published in English peer-reviewed journals (1990-2011) were retrieved. Only those papers that directly addressed treatment options for treatment-resistant depression were retained for extensive review. Results Treatment-resistant depression, a complex clinical problem caused by multiple risk factors, is targeted by integrated therapeutic strategies, which include optimization of medications, a combination of antidepressants, switching of antidepressants, and augmentation with non-antidepressants, psychosocial and cultural therapies, and somatic therapies including electroconvulsive therapy, repetitive transcranial magnetic stimulation, magnetic seizure therapy, deep brain stimulation, transcranial direct current stimulation, and vagus nerve stimulation. As a corollary, more than a third of patients with treatment-resistant depression tend to achieve remission and the rest continue to suffer from residual symptoms. The latter group of patients needs further study to identify the most effective therapeutic modalities. Newer biomarker-based antidepressants and other drugs, together with non-drug strategies, are on the horizon to address further the multiple complex issues of treatment-resistant depression. Conclusion Treatment-resistant depression continues to challenge mental health care providers, and further relevant research involving newer drugs is warranted to improve the quality of life of patients with the disorder.