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Showing papers on "Derivative (chemistry) published in 1982"



Journal ArticleDOI
TL;DR: In this article, the stereoselective synthesis of N-[(s) 1 - carbethoxybutyl)] (s) alanine and of (2S, 3aS, 7aS) 2-t.

101 citations


Journal ArticleDOI
TL;DR: In this article, the electrical resistivities of liquid Li-Sn, Na-Sn and Na-Pb alloys have been measured and the resistivities exhibit distinct maxima close to'stoichiometric' compositions.
Abstract: Electrical resistivities of liquid Li-Sn, Na-Sn and Na-Pb alloys have been measured. The resistivities exhibit distinct maxima close to 'stoichiometric' compositions: Li4Sn, Na4Sn, Na4Sn3 and Na4Pb. At the same compositions the temperature derivative d rho /dT is negative and -d rho /dT assumes extraordinarily large values. The effects are attributed to strong chemical interactions between the components. These interactions tend to reduce the density of states at the Fermi level.

96 citations





Journal ArticleDOI
TL;DR: In this article, the medium-resolution infrared spectrum of malonaldehyde and a doubly deuterated derivative were measured and experimental evidence for a tunneling planar asymmetric hydrogen-bonded structure was presented.

59 citations


Patent
Kenneth Richardson1
01 Jun 1982
TL;DR: In this article, a bis-triazole derivative and its acid addition salts are used for treating fungal infections in animals, including humans, and methods for preparing these compounds from known starting materials are provided.
Abstract: 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol and its pharmaceutically acceptable acid addition salts are disclosed. This particular bis-triazole derivative and its aforesaid salts are useful for treating fungal infections in animals, including humans. Methods for preparing these compounds from known starting materials are provided.

56 citations



Journal ArticleDOI
TL;DR: 1α, 25-Dihydroxyhexafluorovitamin D3, via the corresponding 5, 7-diene, was synthesized by two procedures as discussed by the authors, which consisted of construction of the hexafluoro-25-hydroxy part on the side chain followed by the introduction of a hydroxy group at the 1α-position.
Abstract: 1α, 25-Dihydroxy-26, 26, 26, 27, 27, 27-hexafluorocholesterol was synthesized by two procedures. Cholenic acid was converted to the 1α-hydroxy-24-sulfone derivative and hexafluoroacetone was reacted with the lithiated 24-sulfone. Subsequent removal of the sulfonyl group afforded the hexafluoro-1α, 25-dihydroxy compound. An alternative process consists of construction of the hexafluoro-25-hydroxy part on the side chain followed by the introduction of a hydroxy group at the 1α-position. The hexafluoro derivative was converted to the vitamin D form, 1α, 25-dihydroxyhexafluorovitamin D3, via the corresponding 5, 7-diene.

55 citations



Journal ArticleDOI
TL;DR: Ester-enolate Claisen rearrangement of cis-croytl N- t -Boc-glycinate and iodolactonization of the N-phthaloyl derivative of the resulting unsaturated acid are used as the stereocontrolling steps in a synthesis of the title compound.

Patent
09 Aug 1982
TL;DR: A novel crystal form of ranitidine (N-[2-[[[5-(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl-N'-methyl-2-nitro-1,1-ethenediamine) hydrochloride, designated Form 2, and having favorable filtration and drying characteristics, is characterized by its infra-red spectrum and/or by its x-ray powder diffraction patterns.
Abstract: A novel crystal form of ranitidine (N-[2-[[[5-(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl-N'-methyl-2-nitro-1,1-ethenediamine) hydrochloride, designated Form 2, and having favorable filtration and drying characteristics, is characterized by its infra-red spectrum and/or by its x-ray powder diffraction patterns.

Journal ArticleDOI
TL;DR: The synthesis of tetracyclo[5.4.1.0 4,12.0 9.12 ]dodecan-6-one via an intramolelecular photocycloaddition was described in this paper.

Journal ArticleDOI
Peter Mohr1, Motoo Tori1, Peter Grossen1, Peter Herold1, Christoph Tamm1 
TL;DR: The title compounds have been synthesized starting from verrucarol and diacetoxyscripenol (anguidine), (E, Z)-muconic half ester and a derivative of verru carinic acid.
Abstract: The title compounds have been synthesized starting from verrucarol and diacetoxyscripenol (anguidine), (E, Z)-muconic half ester and a derivative of verrucarinic acid. The latter has been prepared in optically active form from dimethyl 3-methylglutarate.

01 Jan 1982
TL;DR: Spectroscopic measurements show that the integrity of the native structure in the vicinity of the heme c group is maintained in the ruthenium-modified protein.



Patent
19 Jan 1982
TL;DR: In this paper, a compound expressed by formula I is reacted with a haloalkanamide derivative expressed by the corresponding formula II under the dehydrohalogenating reaction conditions.
Abstract: NEW MATERIAL:The titled compound expressed by formula I[R and R are H or lower alkyl; R is OH, lower alkoxyl or NR R (R and R are lower alkyl or cycloalkyl which may have OH as a substituent group, R and R together with the linked N form a saturated heterocyclic ring via an other N); A is lower alkylene] and a salt thereof. EXAMPLE:6-(3-Carboxypropoxy)-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one. USE:A preventing agent and remedy for thrombosis, inhibitor against phosphodiesterase, antiulcer agent, cardiotonic agent, anti-inflammatory agent, hypotensive agent, etc. The dose is 0.1-30mg/kg body weight/day as an active constituent and administered in one to several divided fractions. PROCESS:A hydroxycarbostyril derivative expressed by formula II is reacted with a haloalkanamide derivative expressed by formula III(X is halogen) under the dehydrohalogenating reaction conditions to give the compound expressed by formula I.

Journal ArticleDOI
TL;DR: An arylazido ubiquinone derivative, 2,tdimethoxy5-methyl-6{10-[4-(azid0-2-nitroanilinilinopropionoxy)]decyl} -1,4-benzoquinone, restores about 60% of the electron transfer activity to ubiquin oneand phospholipid-depleted succinateor ubiquinol-cytochrome c reductases, compared to that restored by


Patent
28 Apr 1982
TL;DR: In this paper, N-substituted azaheterocyclic carboxylic acids and their esters, useful as inhibitors of GABA uptake, are prepared by reacting an appropriate N-alkylating derivative with an ester of an N-unsubstitized azahecyclic CARBOYCLIC acid followed by hydrolysis of the ester.
Abstract: N-Substituted azaheterocyclic carboxylic acids and their esters, useful as inhibitors of GABA uptake, are prepared by reacting an appropriate N-alkylating derivative with an ester of an N-unsubstituted azaheterocyclic carboxylic acid followed by hydrolysis of the ester.


Journal ArticleDOI
TL;DR: In this article, a new lupane derivative isolated from Pleurostylia opposita has been assigned the structure 6,β-hydroxy-lup-20(29)-en-3-one, using spectral evidence and chemical interconversions.

Patent
Jouka I. Huttunen1, Turunen Olli T1, Leo Mandel1, Vidar Eklund1, Kurt Ekman1 
27 Jan 1982
TL;DR: In this article, an alkali-soluble cellulose derivative is produced by treating cellulose with liquid ammonia having urea dissolved therein, removing the ammonia, resulting in cellulose having Urea distributed therethrough, and heating the thus obtained cellulose-urea to cause reaction between the urea and cellulose and form alkali soluble carbamate.
Abstract: An alkali-soluble cellulose derivative is produced by treating cellulose with liquid ammonia having urea dissolved therein, removing the ammonia, resulting in cellulose having urea distributed therethrough, and heating the thus obtained cellulose-urea to cause reaction between the urea and cellulose and form alkali-soluble cellulose carbamate. This cellulose carbamate can be precipitated from alkaline solution in the form of cellulose carbamate film or fibre.

Journal ArticleDOI
TL;DR: In this paper, spectroscopy was used to study the binding of Gd3+ and Mn2+ to N-acetyl-2-O-methyl-α-neuraminic acid (2) and to methyl Nacetyl 2-O -methyl-β-nuraminate (3).

Journal ArticleDOI
09 Oct 1982-BMJ
TL;DR: It is time that doctors in this country rejected the omnicompetent and omniresponsible role vis-a-vis life's many problems that society would thrust upon us.
Abstract: group of handicapped patients. The inevitable consequence is that society will continue to pressurise doctors to take similar action against other groups that are a liability to the community. On a more individual level, a life isaccording to the scenario proposed by Dr Crawfurd-to be snuffed out on the basis of a doctor's opinion of the patient's ability to enjoy life in the future. This is being suggested at a time when, by Dr Crawfurd's own admission, \"Considerable advances have been made in the treatment and management of the mentally handicapped.\" What he is suggesting and assuming is a complete contradiction of the Hippocratic tradition that has served well both the medical profession of this country and our patients over many hundreds of years. It is time that doctors in this country rejected the omnicompetent and omniresponsible role vis-a-vis life's many problems that society would thrust upon us. The best guarantee of a trustworthy and competent caring medical profession is still the Hippocratic tradition with its central emphasis on the duty of the doctor to protect the life of each of his individual patients irrespective of the level of their natural physical or mental endowment.


Journal ArticleDOI
TL;DR: The lithio derivative of 2-diethylamino-4-phenylthio-2-butenonitrile is a practical equivalent of the unknown B-carboxyl-vinyl anion, as shown by its facile alkylation with alkyl halides, aldehydes and a-enones, followed by hydrolysis oxidation and elimination as discussed by the authors.

Journal ArticleDOI
TL;DR: The presentation of data in the derivative mode has considerable potential as an aid to the identification of compounds with very similar UV-visible spectra as well as the elimination of broad background absorbance.
Abstract: A preliminary study on the applications of UV-visible derivative spectroscopy to forensic toxicology has been conducted. The presentation of data in the derivative mode has considerable potential as an aid to the identification of compounds with very similar UV-visible spectra. The value of second-derivative spectra for the elimination of broad background absorbance is demonstrated using a liver extract containing a low concentration of amphetamine. Two commercial UV-visible spectrometers have been used which employ different methods of obtaining derivative spectra (electronic differentiation and numeric differentiation) and the limitations due to wavelength shifts produced by the former are discussed.