Showing papers on "Derivative (chemistry) published in 2011"
TL;DR: Computation was used to design a trans-cyclooctene derivative that displays enhanced reactivity in the tetrazine-trans-cycloctene ligation, in which the eight-membered ring is forced to adopt a highly strained 'half-chair' conformation.
Abstract: Computation was used to design a trans-cyclooctene derivative that displays enhanced reactivity in the tetrazine-trans-cycloctene ligation. The optimized derivative is an (E)-bicyclo[6.1.0]non-4-ene with a cis-ring fusion, in which the eight-membered ring is forced to adopt a highly strained 'half-chair' conformation. Toward 3,6-dipyridyl-s-tetrazine in MeOH at 25 °C, the strained derivative is 19 and 27 times more reactive than the parent trans-cyclooctene and 4E-cyclooct-4-enol, respectively. Toward 3,6-diphenyl-s-tetrazine in MeOH at 25 °C, the strained derivative is 160 times more reactive than the parent trans-cyclooctene.
290 citations
189 citations
TL;DR: In this paper, a novel fluorescein derivative, synthesized by the reaction of fluorscein hydrazide and 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone, was evaluated as a chemoselective metal ion sensor.
125 citations
TL;DR: An easy and direct access to POP-type osmium(II) and Osmium (IV) complexes, including OsH4{dbf(PiPr2)2} (dbf[PiPr 2] = 4,6-bis(diisopropylphosphine)dibenzofuran), is reported in this article.
121 citations
TL;DR: The higharomatic stabilization that is conferred by the cyclic delocal-ization of six p electrons distinguishes benzene from its approximately 200 theoretically known isomers and accounts for the ubiquitous occurrence of the benzene motif in manyareas of chemistry.
Abstract: The higharomatic stabilization that is conferred by the cyclic delocal-ization of six p electrons distinguishes benzene from itsapproximately 200 theoretically known isomers and accountsfor the ubiquitous occurrence of the benzene motif in manyareas of chemistry. Despite impressive progress regarding thesynthesis of stable compounds with Si Si p bonds,
117 citations
TL;DR: Crystalline samples of 3(5)-(9-anthryl)pyrazole and its one derivative exhibit interesting piezochromic behaviors with the emission colors differently changing from blue to green and from green to blue, respectively, upon grinding.
104 citations
TL;DR: A novel triazole carboxylic acid, penipanoid A, two new quinazolinone alkaloids, penIPanoids B and C, and a very recently reported quinzolinone derivative were isolated from the marine sediment-derived fungus Penicillium paneum SD-44.
Abstract: A novel triazole carboxylic acid, penipanoid A (1), two new quinazolinone alkaloids, penipanoids B (2) and C (3), and a very recently reported quinazolinone derivative (4) were isolated from the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated by spectroscopic analysis, and the structure for I was confirmed by X-ray crystallographic analysis. Compound 1 represents the first example of a triazole derivative from marine sediment-derived fungi, and compound 2 is a rare quinazolinone derivative having a dihydroimidazole ring system. The cytotoxicity of compounds 1 and 4 and the antimicrobial activity of 1-4 were evaluated.
85 citations
Patent•
19 Apr 2011
TL;DR: In this article, the disclosed bis-carbazole derivative is characterized in being represented by formula (1), where A 1 represents a substituted or unsubstituted nitrogen-containing heterocyclic group having 1-30 ring-forming carbon atoms.
Abstract: The disclosed bis-carbazole derivative is characterized in being represented by formula (1). (In formula (1), A 1 represents a substituted or unsubstituted nitrogen-containing heterocyclic group having 1-30 ring-forming carbon atoms. A 2 represents a substituted or unsubstituted aromatic hydrocarbon group having 6-30 ring-forming carbon atoms, or a substituted or unsubstituted nitrogen-containing heterocyclic group having 1-30 ring-forming carbon atoms. X 1 and X 2 are linkage groups and Y 1 -Y 4 represent substituent groups. p and q represent integers of 1-4, and r and s represent integers of 1-3.)
83 citations
TL;DR: A tin(II) tungstosilicate derivative K(11)H[Sn(4)(SiW(9)O(34))(2)]·25H(2)O with four sandwiched Sn(2+) cations was prepared by reaction of SnCl(2), KCl and Na(10)[α-SiW (9) O(34)]·xH( 2)O.
81 citations
TL;DR: Electronic and electrochemical investigations reveal that adduct 2 has a larger highest occupied molecular orbital-lowest unoccupied molecular orbital (HOMO-LUMO) gap than pristine Sc(2)C( 2)@C(s)(6)-C(82); accordingly, it is more stable.
Abstract: A Sc2C84 isomer, previously assumed to be Sc2@C84, is unambiguously identified as a new carbide cluster metallofullerene Sc2C2@Cs(6)-C82 using both NMR spectroscopy and X-ray crystallography. The 13C-nuclei signal of the internal C2-unit was observed at 244.4 ppm with a 15% 13C-enriched sample. Temperature-dependent dynamic motion of the internal Sc2C2 cluster is also revealed with NMR spectrometry. Moreover, the chemical property of Sc2C2@Cs(6)-C82 is investigated for the first time using 3-triphenylmethyl-5-oxazolidinone (1) which provides a 1,3-dipolar reagent under heating. Regarding the low cage symmetry of this endohedral which contains 44 types of nonequivalent cage carbons, it is surprising to find that only one monoadduct isomer is formed in the reaction. Single-crystal X-ray results of the isolated pyrrolidino derivative Sc2C2@Cs(6)-C82N(CH2)2Trt (2) reveal that the addition takes place at a [6,6]-bond junction, which is far from either of the two Sc atoms. Such a highly regioselective addition ...
79 citations
Patent•
14 Jan 2011
TL;DR: In this article, an indolocarbazoleamide derivative compound having an amine substituent was used as a light emitting material for an organic layer of an organic electroluminescent device.
Abstract: The present invention relates to a compound derivative used in an organic electroluminescent device, and an organic electroluminescent device using the same. More particularly, the present invention relates to an indolocarbazole derivative compound having an amine substituent. When using the indolocarbazole derivative compound as a light emitting material for an organic layer of an organic electroluminescent device, an effect of deriving high luminous efficiency even with a low driving voltage can be provided.
TL;DR: A green fluorescent protein chromophore inspired chemosenor for Zn(2+) was designed and synthesized and specific fluorescence enhancement was observed due to restricted rotation between the 1,10-phenanthroline and imidazolone moieties.
TL;DR: This paper deals with the investigation of the solution of an unified fractional reaction-diffusion equation associated with the Caputo derivative as the time-derivative and Riesz-Feller fractional derivative as The solution is derived by the application of the Laplace and Fourier transforms in closed form in terms of the H-function.
TL;DR: Two cobalt metal-organic frameworks built by amide derivative and organodicarboxyl co-ligands display 3-fold interpenetration of 6(5).8-mok nets which are 4-connected self-catenated nets described theoretically in the early nineties.
TL;DR: In this paper, a rhodamine fluorescent derivative was synthesized easily by a one-step condensation reaction of Rhodamine B ethylenediamine and acetylacetone, which was characterized by X-ray crystallography, NMR, MS and IR spectroscopy.
Abstract: A simple structure, a rhodamine fluorescent derivative, was synthesized easily by a one-step condensation reaction of rhodamine B ethylenediamine and acetylacetone. Its structure was characterized by X-ray crystallography, NMR, MS and IR spectroscopy. As a bi-functional and highly selective “OFF–ON” chemosensor for Fe3+ or Cu2+, the derivative displayed a selective fluorescence enhancement effect only with Fe3+ and an absorption enhancement effect only with Cu2+ by modulating the pH value. In an aqueous ethanol medium, Fe3+ formed a 1:1 complex with the derivative at pH 6, while Cu2+ formed a 1:1 complex at pH 8.5. The limits of detection of the ions were low: 3.9 × 10−9 and 4.8 × 10−8 mol L−1. The derivative also functioned as a fluorescence sensor for CT-DNA, in which the Fe3+ ion that was used as a bridge between the derivative and DNA forming a ternary complex.
TL;DR: AIBX 1a, an o-iodoxybenzoic acid derivative having the trimethylammonium moiety on its phenyl ring, possesses very good solubility in water and distinct oxidative properties from IBX, which is demonstrated in the oxidation of various β-keto esters to the corresponding dehydrogenated products using water as cosolvent.
TL;DR: The obtained results showed that the chitosan-chloroquinoline derivative might be a promising candidate for novel antimicrobial agents for biomedical applications.
TL;DR: Characterization of the organogel of 3 in cyclohexane revealed a porous network, and strong emission of derivative 3 in its nonaggregated form makes it a promising fluorescence sensory material for nitroaromatic compounds.
Abstract: Triphenylene-based discotic liquid crystal 3 bearing 1,2,3-triazole groups has been synthesized using “click” chemistry. Discotic mesogen 3 has good thermal stability, and incorporation of triazole groups results in stabilization of columnar mesophases down to room temperature and formation of organogels in cyclohexane and mixed solvents such as hexane and dichloromethane (4:1 v/v). Characterization of the organogel of 3 in cyclohexane revealed a porous network. However, presence of Cd2+ ions in solution obstructed the self-assembly of this derivative due to preferred interactions between Cd2+ ions and triphenylene units over π–π interactions among triphenylene groups. Further, strong emission of derivative 3 in its nonaggregated form makes it a promising fluorescence sensory material for nitroaromatic compounds.
TL;DR: Reaction of 1, 4-dipotassio-1,1,4,4-tetrakis(trimethylsilyl)tetramethyltetrasilane with [(Me3Si)2N]2Sn led to the formation of an endocyclic distannene via the dimerization of a transient stannylene in the presence of strong donor molecules such as PEt3.
Abstract: Reaction of 1,4-dipotassio-1,1,4,4-tetrakis(trimethylsilyl)tetramethyltetrasilane with [(Me3Si)2N]2Sn led to the formation of an endocyclic distannene via the dimerization of a transient stannylene. In the presence of strong donor molecules such as PEt3, the stannylene could be trapped as adduct. Reaction of the PEt3 derivative with B(C6F5)3 gave rise to the formation of the stannylene B(C6F5)3 adduct.
TL;DR: The 1,2,3-triazolium derivative of the macrocycle shows remarkable selectivity in binding of chloride ion.
Abstract: A novel method for the synthesis of a bile acid-based macrocycle has been developed using click chemistry. The 1,2,3-triazolium derivative of the macrocycle shows remarkable selectivity in binding of chloride ion.
Patent•
21 Sep 2011
TL;DR: In this article, the authors presented a compound having antiviral effects, particularly having growth inhibitory activity on influenza viruses, a preferred example of the compound being a substituted 3-hydroxy-4-pyridone derivative prodrug having cap-dependent endonuclease inhibitory action.
Abstract: The present invention provides a compound having antiviral effects, particularly having growth inhibitory activity on influenza viruses, a preferred example of the compound being a substituted 3-hydroxy-4-pyridone derivative prodrug having cap-dependent endonuclease inhibitory activity.
TL;DR: A new dialkylthio benzo[1,2-b:4,5-b']dithiophene (S-BDT) was designed and synthesized and the polymer S-PBDT was prepared by a Stille coupling reaction.
Patent•
30 Jun 2011
TL;DR: In this article, an optically active diazabicyclooctane derivative defined by formula (F) below is useful as a pharmaceutical intermediate for β-lactamase inhibitor, and a process for preparing the same.
Abstract: Provided are an optically active diazabicyclooctane derivative defined by formula (F) below, which is useful as a pharmaceutical intermediate for β-lactamase inhibitor, and a process for preparing the same. In formula (F) above, R1 represents CO2R, CO2M, or CONH2, wherein R represents a methyl group, a tert-butyl group, an allyl group, a benzyl group, or a 2,5-dioxopyrrolidin-1-yl group, and M represents a hydrogen atom, an inorganic cation, or an organic cation; and R2 represents a benzyl group or an allyl group.
TL;DR: A diarylbutadiyne derivative was synthesized using a few steps and gelified in aromatic solvents, and a polydiacetylene presenting reversible thermochromism properties was obtained.
TL;DR: Conducting polymer hydrogels with unusual 2D building blocks were synthesized in one step via a combination of oxidative coupling polymerization and non-covalent crosslinking of an amphiphilic thiophene derivative, indicating the occurrence of potential-dependent gel-sol transitions.
TL;DR: In this article, a pyrazoline derivative, 2-(4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3yl)phenoxy)acetic acid, was synthesized starting from a chalcone and 3-chlorosin-6-hydrazinylpyridazine and proposed for the determination of Zn 2+ ion with high selectivity and a low detection limit in CH 3 CN:E
Abstract: A novel pyrazoline derivative, 2-(4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenoxy)acetic acid , was synthesized starting from a chalcone and 3-chloro-6-hydrazinylpyridazine and proposed for the determination of Zn 2+ ion with high selectivity and a low detection limit in CH 3 CN:EtOH (90/10, v/v). This sensor formed a 1:1 complex with Zn 2+ and showed a fluorescent enhancement with good tolerance of other metal ions.
Patent•
28 Apr 2011TL;DR: In this article, a quinoxaline derivative compound is introduced, which relates to new quoxaline derivatives, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and to the use of such compounds in the treatment of diseases, eg cancer.
Abstract: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, eg cancer
Patent•
20 Apr 2011
TL;DR: A biscarbazole derivative of the invention is represented by a formula (1) below as discussed by the authors, where A represents a substituted or unsubstituted nitrogen-containing heterocyclic group having 1 to 30 ring carbon atoms; A2 represents an aromatic hydrocarbon group having 6 to 30 rings carbon atoms, or substituted or unsaturated nitrogen-based HOG having 1-30 ring atoms; X1 and X2 each are a linking group; Y1 to Y4 each represent a substituent.
Abstract: A biscarbazole derivative of the invention is represented by a formula (1) below. In the formula (1): A1 represents a substituted or unsubstituted nitrogen-containing heterocyclic group having 1 to 30 ring carbon atoms; A2 represents a substituted or unsubstituted aromatic hydrocarbon group having 6 to 30 ring carbon atoms, or substituted or unsubstituted nitrogen-containing heterocyclic group having 1 to 30 ring carbon atoms; X1 and X2 each are a linking group; Y1 to Y4 each represent a substituent; p and q represent an integer of 1 to 4; and r and s represent an integer of 1 to 3.
TL;DR: Oxosumanenes were synthesized through benzylic oxidation to exhibit the expanded π-conjugation compared to sumanene and single-crystal X-ray analysis of monooxosumanene showed columnar ρ-stacking in a concave-convex fashion.
Abstract: Oxosumanenes were synthesized through benzylic oxidation. The electronic and redox properties were revealed to exhibit the expanded π-conjugation compared to sumanene. Single-crystal X-ray analysis of monooxosumanene showed columnar π-stacking in a concave–convex fashion. Stereoselective trimethylation of the trioxo derivative was performed via 1,2-addition to the carbonyl groups.
TL;DR: A new positively charged fluorescent probe poly(p-phenylene vinylene) derivative (PPV-1) derivative has been developed for the detection of an important biological process, apoptosis, in a simple and fluorescent label-free way.