Topic
Derivative (chemistry)
About: Derivative (chemistry) is a research topic. Over the lifetime, 59502 publications have been published within this topic receiving 326161 citations. The topic is also known as: chemical derivative.
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TL;DR: In this article, a diamido diacid diphenyl fulleroid derivative was designed specifically to inhibit an HIV enzyme and detailed synthesis and mass spectrometric analysis of the water-soluble, biologically active methanofullerene are described.
Abstract: A diamido diacid diphenyl fulleroid derivative was designed specifically to inhibit an HIV enzyme. The detailed synthesis and mass spectrometric analysis of the water-soluble, biologically active methanofullerene are described. The compound was prepared in three steps from C[sub 60] via a suitably diphenyldiazomethane. High-resolution mass spectrometric analysis was possible only under mild matrix-assisted laser desorption/ionization Fourier transform mass spectrometry conditions. Direct infrared or ultraviolet laser desorption resulted exclusively in observation of C[sub 60] ions, in either positive or negative mode. 13 refs., 3 figs.
413 citations
Patent•
29 Jun 1987
TL;DR: A poly-label oligonucleotide having a plurality of labels, comprising labels carried on a polylysine and having the poly-lysine introduced on the extension from 5'- and/or 3'-end through phosphate group is useful as a probe for hybridization as mentioned in this paper.
Abstract: A poly-labelled oligonucleotide having a plurality of labels, comprising labels carried on a polylysine and having the polylysine introduced on the extension from 5'- and/or 3'-end through phosphate group is useful as a probe for hybridization.
411 citations
394 citations
TL;DR: It was shown that the difficultly accessible isopropylidene side chain of spirotryprostatin A is not necessary for biological activity and three analogues lacking the diketopiperazine system were shown to be quite active as cell cycle inhibitors.
Abstract: The total synthesis of the title compound has been accomplished. A key step involves the oxidative rearrangement of the β-carboline derivative to an oxindole via the action of N-bromosuccinimide. From this point, a diketopiperazine was introduced. A thiophenyl group served as a precursor of the isopropylidene function. Implementation of the same sort of chemistry starting with a methoxytryptophan derivative led to the parent structures. Furthermore, it was shown that the difficultly accessible isopropylidene side chain of spirotryprostatin A is not necessary for biological activity. Moreover, three analogues lacking the diketopiperazine system were shown to be quite active as cell cycle inhibitors.
387 citations
TL;DR: This work has investigated in more detail some new properties of this derivative and some useful related theorems and some new definitions have been introduced.
Abstract: Abstract Recently, the conformable derivative and its properties have been introduced. In this work we have investigated in more detail some new properties of this derivative and we have proved some useful related theorems. Also, some new definitions have been introduced.
386 citations