Topic
Detection limit
About: Detection limit is a research topic. Over the lifetime, 34379 publications have been published within this topic receiving 644817 citations. The topic is also known as: limit of detection & lower detection limit.
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TL;DR: A method for the concentration of dilute samples on a column and its application to the analysis of biomedical mixtures is described and the optimal choice of conditions is discussed.
112 citations
TL;DR: Attomole quantities of 4-(dimethylamino)azobenzene-4'-sulfonyl chloride derivatized amino acids are separated by using capillary zone electrophoresis in a mixed acetonitrile/aqueous buffer system with superiority to the best fluorescence detection limit reported for chromatographic separation of amino acids.
Abstract: Attomole quantities of 4-(dimethylamino)azobenzene-4'-sulfonyl chloride derivatized amino acids are separated by using capillary zone electrophoresis in a mixed acetonitrile/aqueous buffer system. Detection is performed with an on-column thermooptical absorbance detection technique based on a 130-mW argon ion pump laser. Detection limits for the concentration of analyte injected onto the column range from 5 x 10(-8) M for methionine to 5 x 10(-7) M for aspartic acid. Only 37 amol of methionine and 450 amol of aspartic acid are contained within the subnanoliter injection volume. It is interesting to note that these limits are a factor of 4 superior to the best fluorescence detection limit reported for chromatographic separation of amino acids. A subnanoliter sample of derivatized human urine was analyzed with this technique; quantities of amino acids contained within the sample are 3 orders of magnitude greater than the detection limit.
112 citations
TL;DR: In this article, the as-prepared CuO-TiO 2 hybrid nanocomposites were decorated on the glass carbon electrode as the nonenzymatic electrochemical nanosensor for the sensitive and selective detection of methyl parathion.
Abstract: Detection of pesticides in ground water has become a very important and crucial research area due to the rapid expansion of agriculture and stringent environmental protection acts. In this paper, the as-prepared CuO-TiO 2 hybrid nanocomposites were decorated on the glass carbon electrode as the nonenzymatic electrochemical nanosensor for the sensitive and selective detection of methyl parathion. The electrochemical behavior of the modified electrode was investigated by cyclic voltammetry, showing that the modified electrode can be used for methyl parathion detection. Differential pulse voltammetry was applied to evaluate methyl parathion detection ability under optimized experimental conditions, and found the modified electrode can detect methyl parathion sensitively in a wide dynamic detection range from 0 ppb to 2000 ppb with a lower limit of detection (LOD) of 1.21 ppb. In addition, other interfering materials have no any influences on the detection of methyl parathion. Furthermore, the modified electrode has also been used for methyl parathion detection in the actual ground water samples, and showed efficient sensing ability. The electrochemical sensor developed would have great potentiality for methyl parathion sensing and provide new insights into the detection of other organophosphorous pesticides in the ground water.
112 citations
TL;DR: Based on the chemiluminescence (CL) phenomena of folic acid in peroxomonosulfate-cobalt(II) system, a rapid and sensitive CL method was developed and has been successfully applied to the determination of folics acid in tablets and human urine.
112 citations
TL;DR: Immobilization of glucose oxidase in electropolymerized polypyrrole film on the surface of a platinum wire electrode, provides a convenient sensor for flow-injection glucose determination and allows quick electrode renewal before each series of measurements.
112 citations