Topic
Detection limit
About: Detection limit is a research topic. Over the lifetime, 34379 publications have been published within this topic receiving 644817 citations. The topic is also known as: limit of detection & lower detection limit.
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TL;DR: Tests on artificial serum proved that l-lactate can be determined practically without interferences from commonly interfering compounds such as urate, paracetamol and l-ascorbate.
102 citations
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TL;DR: The whole procedure showed to be conveniently fast, efficient and economical for extraction of fluoxetine from environmental and biological samples.
102 citations
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TL;DR: The reversed-phase HPLC assay coupled with electrochemical detection for simultaneously measuring plasma levels of norepinephrine, epinephrine, dopamine, and 3,4-dihydroxyphenylacetic acid (DOPAC) has been applied successfully to measure plasma concentrations of these catecholamines in humans, rabbits and rats.
102 citations
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TL;DR: In this article, a direct injection nebulizer was used with packed microcolumns for anion chromatography and size exclusion chromatography (SEC) and two Se species (SeO[sub 3][sup 2[minus]) were separated by AC with detection limits of 15 pg of Se.
Abstract: A direct injection nebulizer (DIN) is used with packed microcolumns for anion chromatography (AC) and size exclusion chromatography (SEC). Two Se species (SeO[sub 3][sup 2[minus]] and SeO[sub 4][sup 2[minus]]) are separated by AC with detection limits of 15 pg of Se. The isotope ratio [sup 74]Se/[sup 78]Se can be measured with a relative standard deviation of 0.5% on 25 ng of each Se species during the actual chromatographic separation. Proteins in human serum are separated by SEC without sample pretreatment. The metals present in each molecular weight fraction are determined by ICP-MS with detection limits of 0.5-3 pg of metal. These absolute detection limits are 1-2 orders of magnitude better than those obtained with conventional nebulizers. 56 refs., 3 figs., 7 tabs.
102 citations
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TL;DR: A new version of the direct injection nebulizer (DIN) is used to interface liquid chromatographic separations with element-selective detection using inductively coupled plasma mass spectrometry (ICP-MS).
Abstract: A new version of the direct injection nebulizer (DIN) is used to interface liquid chromatographic (LC) separations with element-selective detection using inductively coupled plasma mass spectrometry (ICP-MS). The DIN injects all of the sample into the ICP and has a dead volume of less than 1 µl. Charged species of arsenic and tin are separated as ion pairs on a micro-scale (1 mm i.d.), packed, reversed-phase column. Detection limits are 0.2–0.6 pg for arsenic and 8–10 pg for tin. For methanol + water eluents, the signal is highest at 25% methanol and stays within 25% of this maximum as the methanol fraction is varied from 20 to 80%. Compared with LC–ICP-MS with conventional nebulizers, the absolute detection limits and chromatographic resolution are substantially superior, and the dependence of analyte signal on solvent composition is somewhat less severe with the DIN.
102 citations