Topic
Detection limit
About: Detection limit is a research topic. Over the lifetime, 34379 publications have been published within this topic receiving 644817 citations. The topic is also known as: limit of detection & lower detection limit.
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TL;DR: Surface modification of MIP particlefs packed in the pretreatment column provided selective affinity and on-line concentration of low levels of E2 while simultaneously eliminating sample matrix interference, resulting in a significant increase in sensitivity and reproducibility for liquid chromatography-mass spectrometry analysis of E 2 in river water sample.
97 citations
TL;DR: An amperometric method for alkaline phosphatase is described and compared to the most widely used spectrophotometric method, which has a detection limit of 7 nM for the product of the enzyme reaction, which is almost 20 times better than the spectrophOTometric method.
97 citations
TL;DR: A new method utilizing high-performance liquid chromatography with electrochemical detection for the determination of unconjugated 3-methoxy-4-hydroxyphenylglycol, a major metabolite of norepinephrine, in human plasma is described.
97 citations
TL;DR: In this article, an ion sensitive field effect transistors (ENFET) was used to detect hypochlorite couple (HOC1/OC1−) concentration in water solutions.
Abstract: Biochemical assay for hypochlorite couple (HOC1/OC1−) concentration in water solutions was developed. Acetylcholine sensitive enzyme sensor based on ion sensitive field effect transistors (ENFET) was prepared by cross-linking acetylcholinesterase (AChE) with bovine serum albumin in saturated glutaraldehyde vapour on the sensor chip and used for such purpose. The corresponding detection limit was at least about 10−5 M of HOC1/OC1− at pH 6.0-6.5. At these pH from 90% up to 100% of hypochlorite species were under the form of hypochlorous acid. Sensitivity of the developed biosensor to hypochlorite species depends on the concentration of acetylcholine and inhibition time. This phenomenon can be used to increase the sensitivity of such biosensor to hypochlorite species concentration and detection limit for inhibitor analysis can be decreased. The use of a pyridine-2-aldoxime methyliodide (PAM-2), a well known restoration activity agent for cholinesterases, did not give positive effect. So it can be concluded that the inhibition of AChE by HOCl/OCl− is due to another mechanism than those involved in the case of an inhibition by organophosphorous pesticides.
97 citations
TL;DR: A novel, green, facile and dual turn-off/on sensor for detection of Hg2+ and I- was developed based on carbon dots that showed good sensitivity and selectivity with respect to interference ions and was successfully used in tap, river and mineral waters and fish samples.
97 citations