Topic
Detection limit
About: Detection limit is a research topic. Over the lifetime, 34379 publications have been published within this topic receiving 644817 citations. The topic is also known as: limit of detection & lower detection limit.
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TL;DR: A sensitive fluorimetric method, in which catecholamines are concentrated from plasma by liquid-liquid extraction and derivatized with the selective fluorescent agent 1,2-diphenylethyl-enediamine prior to chromatography, shows good correlation and regression lines are close to lines of identity.
230 citations
TL;DR: The experimental results showed that the stable N-GQDs could be used for the detection of H2O2 and glucose over a wide range of pH and temperature, offering a simple, highly selective and sensitive approach for their colorimetric sensing.
229 citations
TL;DR: The hybrid-based electrode sensor showed attractive electrochemical performance for sensitive and selective nonenzymatic detection of hydrogen peroxide and could sensitively detect a trace amount of H2O2 in a nanomolar level released from living tumor cells (HeLa and HepG2).
Abstract: A new kind of two-dimensional (2-D) hybrid material (RGO-PMS@AuNPs), fabricated by the immobilization of ultrasmall gold nanoparticles (AuNPs, ∼3 nm) onto sandwich-like periodic mesopourous silica (PMS) coated reduced graphene oxide (RGO), was employed for both electrocatalytic application and cancer cell detection. The hybrid-based electrode sensor showed attractive electrochemical performance for sensitive and selective nonenzymatic detection of hydrogen peroxide (H2O2) in 0.1 M phosphate buffered saline, with wide linear detection range (0.5 μM to 50 mM), low detection limit (60 nM), and good sensitivity (39.2 μA mM–1 cm–2), and without any interference by common interfering agents. In addition, the sensor exhibited a high capability for glucose sensing and H2O2 detection in human urine. More interestingly, the hybrid was found to be nontoxic, and the electrode sensor could sensitively detect a trace amount of H2O2 in a nanomolar level released from living tumor cells (HeLa and HepG2). Because the hybr...
227 citations
TL;DR: The present nanosensor for trypsin detection possesses red emission, excellent biocompatibility, high selectivity, and good stability and was demonstrated in real urine samples, which suggested its potential for diagnostic purposes.
227 citations
TL;DR: In this article, the authors improved the speed, specificity, and limit of determination of the aqueous acid extraction thiobarbituric acid (TBA) method for measuring malonaldehyde (MA) as a marker of lipid peroxidation in ground beef.
Abstract: The objectives of this study were to improve the speed, specificity, and limit of determination of the aqueous acid extraction thiobarbituric acid (TBA) method for measuring malonaldehyde (MA) as a marker of lipid peroxidation in ground beef. The TBA reaction time was reduced from 30 to 5 min at 94±1 o C by increasing the concentration of TBA from 20 to 80 mM. The TBA-reactive substances (TBARS) in ground beef extracts and MA standard solution were stable for up to 2 and 12 days, respectively, in 5% (w/v) trichloroacetic acid (TCA) at 4 o C
225 citations