Topic
Detection limit
About: Detection limit is a research topic. Over the lifetime, 34379 publications have been published within this topic receiving 644817 citations. The topic is also known as: limit of detection & lower detection limit.
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TL;DR: In this paper, the concentration of hydrogen peroxide (H2O2) in distilled water, drinking water and in different types of surface and rain waters can be easily determined by a photometric method in which N,N-diethyl-p-phenylenediamine (DPD) is oxidized by a peroxidase catalyzed reaction.
819 citations
TL;DR: In this article, a solution-processed double perovskite Cs2AgBiBr6 single crystals are used to make a sensitive X-ray detector with a minimum detectable dose rate as low as 59.7 nGyair's−1.
Abstract: Sensitive X-ray detection is crucial for medical diagnosis, industrial inspection and scientific research. The recently described hybrid lead halide perovskites have demonstrated low-cost fabrication and outstanding performance for direct X-ray detection, but they all contain toxic Pb in a soluble form. Here, we report sensitive X-ray detectors using solution-processed double perovskite Cs2AgBiBr6 single crystals. Through thermal annealing and surface treatment, we largely eliminate Ag+/Bi3+ disordering and improve the crystal resistivity, resulting in a detector with a minimum detectable dose rate as low as 59.7 nGyair s−1, comparable to the latest record of 0.036 μGyair s−1 using CH3NH3PbBr3 single crystals. Suppressed ion migration in Cs2AgBiBr6 permits relatively large external bias, guaranteeing efficient charge collection without a substantial increase in noise current and thus enabling the low detection limit. Double perovskite Cs2AgBiBr6 single crystals are used to make a sensitive X-ray detector. The device exhibits a high sensitivity of 105 µC Gyair
−1 cm−2 and a low detection limit of 59.7 nGyairs−1, and demonstrates long-term operational stability.
812 citations
TL;DR: Co3O4 nanofibers have great potential applications in the development of sensors for enzyme-free detection of glucose and are demonstrated to have good reproducibility and selectivity in alkaline solution.
623 citations
TL;DR: In this article, the performance of 2,5-dihydroxybenzoic acid (DHB) as a matrix for laser desorption-ionization mass spectrometry of proteins is described.
573 citations
TL;DR: A universal platform that allows for the enrichment and delivery of analytes into the SERS-sensitive sites in both aqueous and nonaqueous fluids, and its subsequent quantitative detection of Rhodamine 6G down to ∼75 fM level (10−15 mol⋅L−1).
Abstract: Detecting target analytes with high specificity and sensitivity in any fluid is of fundamental importance to analytical science and technology. Surface-enhanced Raman scattering (SERS) has proven to be capable of detecting single molecules with high specificity, but achieving single-molecule sensitivity in any highly diluted solutions remains a challenge. Here we demonstrate a universal platform that allows for the enrichment and delivery of analytes into the SERS-sensitive sites in both aqueous and nonaqueous fluids, and its subsequent quantitative detection of Rhodamine 6G (R6G) down to ∼75 fM level (10(-15) mol⋅L(-1)). Our platform, termed slippery liquid-infused porous surface-enhanced Raman scattering (SLIPSERS), is based on a slippery, omniphobic substrate that enables the complete concentration of analytes and SERS substrates (e.g., Au nanoparticles) within an evaporating liquid droplet. Combining our SLIPSERS platform with a SERS mapping technique, we have systematically quantified the probability, p(c), of detecting R6G molecules at concentrations c ranging from 750 fM (p > 90%) down to 75 aM (10(-18) mol⋅L(-1)) levels (p ≤ 1.4%). The ability to detect analytes down to attomolar level is the lowest limit of detection for any SERS-based detection reported thus far. We have shown that analytes present in liquid, solid, or air phases can be extracted using a suitable liquid solvent and subsequently detected through SLIPSERS. Based on this platform, we have further demonstrated ultrasensitive detection of chemical and biological molecules as well as environmental contaminants within a broad range of common fluids for potential applications related to analytical chemistry, molecular diagnostics, environmental monitoring, and national security.
553 citations