scispace - formally typeset
Search or ask a question
Topic

Developmental plasticity

About: Developmental plasticity is a research topic. Over the lifetime, 1721 publications have been published within this topic receiving 103438 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: Evidence and viewpoints on developmental plasticity in the cerebral cortex are reviewed and some specific predictions about the limits and extent of plasticity are assessed through both empirical evidence from infants and simulations on simple cortical network models.
Abstract: In this paper I review evidence and viewpoints on developmental plasticity in the cerebral cortex. Although there is some degree of plasticity in the cortex during early postnatal life in the human infant, this plasticity is constrained by various factors. Three working hypotheses about postnatal cortical specialization of function are advanced, and some specific predictions about the limits and extent of plasticity are assessed through both empirical evidence from infants and simulations on simple cortical network models.

44 citations

Journal ArticleDOI
TL;DR: The approach of high-density cDNA array hybridization can be used as a useful tool for examining a complex phenomenon of developmental plasticity since it is amenable to multiple developmental stage gene expression comparisons.

44 citations

Book ChapterDOI
Igor Timofeev1
TL;DR: It is suggested thatslow oscillation is intrinsic property of cortical network and brain homeostatic mechanisms are tuned to use all forms of plasticity to bring cortical network to the state of slow oscillation.
Abstract: Throughout life, thalamocortical (TC) network alternates between activated states (wake or rapid eye movement sleep) and slow oscillatory state dominating slow-wave sleep. The patterns of neuronal firing are different during these distinct states. I propose that due to relatively regular firing, the activated states preset some steady state synaptic plasticity and that the silent periods of slow-wave sleep contribute to a release from this steady state synaptic plasticity. In this respect, I discuss how states of vigilance affect short-, mid-, and long-term synaptic plasticity, intrinsic neuronal plasticity, as well as homeostatic plasticity. Finally, I suggest that slow oscillation is intrinsic property of cortical network and brain homeostatic mechanisms are tuned to use all forms of plasticity to bring cortical network to the state of slow oscillation. However, prolonged and profound shift from this homeostatic balance could lead to development of paroxysmal hyperexcitability and seizures as in the case of brain trauma.

44 citations

BookDOI
01 Jan 2004
TL;DR: The Avian Song Control System is a model for Understanding Changes in Neural Structure and Function and Plasticity in the Auditory System of Insects.
Abstract: 1 Overview: Development and Plasticity of the Central Auditory System.- 2 Assembling, Connecting, and Maintaining the Cochlear Nucleus.- 3 Developmental Changes and Cellular Plasticity in the Superior Olivary Complex.- 4 Plasticity of Binaural Systems.- 5 Experience-Dependent Response Plasticity in the Auditory Cortex: Issues, Characteristics, Mechanisms, and Functions.- 6 The Avian Song Control System: A Model for Understanding Changes in Neural Structure and Function.- 7 Plasticity in the Auditory System of Insects.

44 citations

Journal ArticleDOI
TL;DR: An emerging principle of astrocyte plasticity is that it is often induced by neuronal activity, reinforcing the emerging understanding of the working brain as a constant interaction between neurons and glial cells.
Abstract: Astrocytes are increasingly implicated in a range of functions in the brain, many of which were previously ascribed to neurons. Much of the prevailing interest centers on the role of astrocytes in the modulation of synaptic transmission and their involvement in the induction of forms of plasticity such as long-term potentiation and long-term depression. However, there is also an increasing realization that astrocytes themselves can undergo plasticity. This plasticity may be manifest as changes in protein expression which may modify calcium activity within the cells, changes in morphology that affect the environment of the synapse and the extracellular space, or changes in gap junction astrocyte coupling that modify the transfer of ions and metabolites through astrocyte networks. Plasticity in the way that astrocytes release gliotransmitters can also have direct effects on synaptic activity and neuronal excitability. Astrocyte plasticity can potentially have profound effects on neuronal network activity and be recruited in pathological conditions. An emerging principle of astrocyte plasticity is that it is often induced by neuronal activity, reinforcing our emerging understanding of the working brain as a constant interaction between neurons and glial cells.

44 citations


Network Information
Related Topics (5)
Hippocampus
34.9K papers, 1.9M citations
83% related
Hippocampal formation
30.6K papers, 1.7M citations
82% related
Glutamate receptor
33.5K papers, 1.8M citations
82% related
Prefrontal cortex
24K papers, 1.9M citations
81% related
Dopaminergic
29K papers, 1.4M citations
80% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202316
202244
202172
202076
201953
201864