Topic
Developmental plasticity
About: Developmental plasticity is a research topic. Over the lifetime, 1721 publications have been published within this topic receiving 103438 citations.
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TL;DR: It is demonstrated that highland deer mice have enhanced thermogenic capacities under hypoxia, and that performance differences between highland and lowland mice persist when individuals are born and reared under common-garden conditions, suggesting that differences in thermogenic capacity have a genetic basis.
Abstract: Small mammals face especially severe thermoregulatory challenges at high altitude because the reduced O2 availability constrains the capacity for aerobic thermogenesis. Adaptive enhancement of thermogenic performance under hypoxic conditions may be achieved via physiological adjustments that occur within the lifetime of individuals (phenotypic plasticity) and/or genetically based changes that occur across generations, but their relative contributions to performance differences between highland and lowland natives are unclear. Here, we examined potentially evolved differences in thermogenic performance between populations of deer mice ( Peromyscus maniculatus ) that are native to different altitudes. The purpose of the study was to assess the contribution of phenotypic plasticity to population differences in thermogenic performance under hypoxia. We used a common-garden deacclimation experiment to demonstrate that highland deer mice have enhanced thermogenic capacities under hypoxia, and that performance differences between highland and lowland mice persist when individuals are born and reared under common-garden conditions, suggesting that differences in thermogenic capacity have a genetic basis. Conversely, population differences in thermogenic endurance appear to be entirely attributable to physiological plasticity during adulthood. These combined results reveal distinct sources of phenotypic plasticity for different aspects of thermogenic performance, and suggest that thermogenic capacity and endurance may have different mechanistic underpinnings.
81 citations
TL;DR: A body of research has emerged that is shaping a new view of functional developmental plasticity, in which neurobehavioral outcome is set by the biological risk associated with a medical condition and moderated by age and development, the time since onset of the condition, and the reserve available within the child, family, school, and community.
80 citations
TL;DR: It is determined that unless a minimum of four pluripotent cells is established before implantation, development will arrest, and this failure can be rescued by modulating Fgf and Wnt signaling to enhance pluripotency, allowing the generation of monozygotic twins, which is an otherwise rare phenomenon.
80 citations
01 Jan 2006
80 citations
TL;DR: The concept of the critical window is revealed to be overarching in cardio-respiratory development, and events originating within a critical window are shown to result in modified developmental trajectories and, ultimately, modified adult phenotype.
79 citations