Topic
Dialysis (biochemistry)
About: Dialysis (biochemistry) is a research topic. Over the lifetime, 8723 publications have been published within this topic receiving 106777 citations.
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TL;DR: The fact that brain gray-matter aluminum was higher in all patients with the dialysis-associated encephalopathy syndrome than any of the control subjects or other uremic patients on dialysis suggests that this syndrome may be due to aluminum in intoxication.
Abstract: The aluminum content of muscle, bone and brain was measured in control subjects and in uremic patients on dialysis who had been maintained on phosphate-binding aluminum gels. The mean musc...
1,555 citations
TL;DR: The results suggest that mesothelial cells have an active role in the structural and functional alteration of the peritoneum during peritoneal dialysis, and suggest potential targets for the design of new dialysis solutions and markers for the monitoring of patients.
Abstract: Background During continuous ambulatory peritoneal dialysis, the peritoneum is exposed to bioincompatible dialysis fluids that cause denudation of mesothelial cells and, ultimately, tissue fibrosis and failure of ultrafiltration. However, the mechanism of this process has yet to be elucidated. Methods Mesothelial cells isolated from effluents in dialysis fluid from patients undergoing continuous ambulatory peritoneal dialysis were phenotypically characterized by flow cytometry, confocal immunofluorescence, Western blotting, and reverse-transcriptase polymerase chain reaction. These cells were compared with mesothelial cells from omentum and treated with various stimuli in vitro to mimic the transdifferentiation observed during continuous ambulatory peritoneal dialysis. Results were confirmed in vivo by immunohistochemical analysis performed on peritoneal-biopsy specimens. Results Soon after dialysis is initiated, peritoneal mesothelial cells undergo a transition from an epithelial phenotype to a mesenchym...
721 citations
TL;DR: A rapid technique for the determination of the dissociation constant and the number of binding sites of an enzyme-substrate complex has been developed based on measuring the rate of dialysis of radioactive substrate from an enzyme -substrate equilibrium mixture.
482 citations
410 citations