Showing papers on "Dichlorophenylphosphine published in 2011"

New cyclopentenyl-linked [NPN] ligands and their coordination chemistry with zirconium: synthesis of a dinuclear side-on-bound dinitrogen complex.

Abstract: The synthesis and characterization of two 1,2-cyclopentyl-bridged diiminophosphine proligands, CY5[NPN]DMPH2 (CY5 = cyclopentylidene; DMP = 2,6-Me2C6H3) and CY5[NPN]DIPPH2 (DIPP = 2,6-iPr2C6H3), are presented, and tautomerization to the corresponding 1,2-cyclopentenyl-bridged enamineimine phosphine precursors is reported. These two new proligands are obtained by deprotonation of N-DMP- or N-DIPP-cyclopentylideneimine (N-DMP, 2,6-dimethylphenyl; N-DIPP, 2,6-diisopropylphenyl) and the subsequent addition of 0.5 equiv of dichlorophenylphosphine. Each ligand precursor exists as a mixture of isomers that consist of the diimine, enamineimine, and dienamine tautomers and corresponding stereoisomers, each of which could be identified. The bis(dimethylamido)zirconium complexes CY5[NPN]DMPZr(NMe2)2 and CY5[NPN]DIPPZr(NMe2)2 were prepared directly from the neutral proligands and Zr(NMe2)4 via protonolysis. Exchange of the dimethylamido ligands in the latter complexes for chlorides and iodides takes place upon reacti...

Synthesis and evaluation of novel phosphasugar anticancer agents

Abstract: Starting materials of phosphasugars, 1-phenyl-2-phospholene 1-oxides, were pre- pared from dienes and phenylphosphonous dichloride (dichlorophenylphosphine). Several substituted novel phosphasugars (3- or 4-halo-substituted)-1-phenyl-2-phospholene 1-oxides as well as 1-phenyl-2-phospholane 1-oxides were prepared from 2-phospholenes. The syn- thesized compounds were evaluated for their antitumor activities against the leukemia cell lines (U937 and K562) by in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bro- mide (MTT) assay. 2,3,4-Tribromo-3-methyl-1-phenylphospholane 1-oxide showed superior antitumor activity against U937 and K562 cell lines in a comparative evaluation with Glivec. The analysis by flow cytometry implied that 2,3-dibromo-3-methyl-1-phenylphospholane 1-oxide induced apoptosis to leukemia cell lines.

Method for preparing phenyl hypophosphite flame retardant

Abstract: The invention discloses a method for preparing a phenyl hypophosphite flame retardant, which comprises the following steps of: adding dichlorophenylphosphine into water at the temperature of between 40 and 100 DEG C within 1 to 6 hours in a reaction kettle with a stirring and refluxing device, and continuously stirring; keeping the temperature to be between 40 and 100 DEG C, and maintaining reaction for 1 to 6 hours; and reducing the temperature to room temperature, regulating the pH of reaction liquid to be between 6 and 8 by using an alkaline material, adding metal salt within 0.5 to 3 hours, maintaining reaction for 1 to 2 hours, filtering, and drying to obtain the phenyl hypophosphite flame retardant, wherein the molar ratio of the water to the dichlorophenylphosphine to the metal salt is 1L:(1-7mol):(1-5mol). Phenyl hypophosphite is prepared from a simple raw material, an intermediate product is not required to be separated, the method is simple, the reaction period is short, conditions are mild, cost is low, and the obtained product has high heat stability.