Topic
Diet induced thermogenesis
About: Diet induced thermogenesis is a research topic. Over the lifetime, 394 publications have been published within this topic receiving 22133 citations.
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TL;DR: Several ways in which the calculation of metabolic rate by indirect calorimetry can be simplified are described and how the effect of protein metabolism can be included with a minimum of trouble are shown.
Abstract: A curious fact in the estimation of metabolic rate by indirect calorimetry is that the normal 'exact' method of calculation is so cumbersome that the effect of protein metabolism is commonly ignored. Moreover, the total respiratory quotient is used to assign to the oxygen consumed a calorie value which is appropriate only to the non-protein respiratory quotient. This paper describes several ways in which the calculation can be simplified and shows how the effect of protein metabolism can be included with a minimum of trouble. The derivation of the calorie value of 1 litre of oxygen is the first step.
5,080 citations
TL;DR: Measurement of energy balance during voluntary over-eating in rats unequivocally establishes the quantitative importance of diet-induced thermogenesis in energy balance and suggests that this tissue may determine metabolic efficiency and resistance to obesity.
Abstract: Measurement of energy balance during voluntary overeating in rats unequivocally establishes the quantitative importance of diet-induced thermogenesis in energy balance. Like cold-induced thermogenesis, this form of heat production involves changes in the activity of the sympathetic nervous system and brown adipose tissue which suggest that this tissue may determine metabolic efficiency and resistance to obesity.
1,432 citations
TL;DR: It is concluded that ambient temperature is qualitatively determinative for the outcome of metabolic studies, that no other protein and no other mechanism can substitute for UCP1 in mediating diet-induced adrenergic thermogenesis, and that U CP1 activity can be determinativeFor obesity development in mice and possibly in humans.
1,211 citations
TL;DR: It is established that βARs are necessary for diet- induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity.
Abstract: Excessive caloric intake is thought to be sensed by the brain, which then activates thermogenesis as a means of preventing obesity. The sympathetic nervous system, through β-adrenergic receptor (βAR) action on target tissues, is likely the efferent arm of this homeostatic mechanism. To test this hypothesis, we created mice that lack the three known βARs (β-less mice). β-less mice on a Chow diet had a reduced metabolic rate and were slightly obese. On a high-fat diet, β-less mice, in contrast to wild-type mice, developed massive obesity that was due entirely to a failure of diet-induced thermogenesis. These findings establish that βARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in the body9s defense against diet-induced obesity.
758 citations
TL;DR: A critical summary of studies that focused on physiologic measures relating to subjectively rated appetite, actual food intake, or both and made a distinction between biomarkers of satiation or meal termination and those of meal initiation related to satiety and between markers in the brain [central nervous system (CNS)] and those related to signals from the periphery to the CNS.
548 citations