Topic
Differential scanning calorimetry
About: Differential scanning calorimetry is a research topic. Over the lifetime, 50315 publications have been published within this topic receiving 1152335 citations. The topic is also known as: DSC.
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TL;DR: In this article, the optimal concentration of alumina nanoparticles in doped molten Hitec that maximizes its specific heat capacity was investigated, and a simplified model of the interfacial area was developed to explain the optimal concentrations.
184 citations
TL;DR: A DSC method was developed for measuring the solubility of crystalline drugs in polymers and has the potential of providing useful data for designing physically stable formulations of amorphous drugs.
Abstract: Amorphous pharmaceuticals, a viable approach to enhancing bioavailability, must be stable against crystallization. An amorphous drug can be stabilized by dispersing it in a polymer matrix. To implement this approach, it is desirable to know the drug’s solubility in the chosen polymer, which defines the maximal drug loading without risk of crystallization. Measuring the solubility of a crystalline drug in a polymer is difficult because the high viscosity of polymers makes achieving solubility equilibrium difficult. Differential Scanning Calorimetry (DSC) was used to detect dissolution endpoints of solute/polymer mixtures prepared by cryomilling. This method was validated against other solubility-indicating methods. The solubilities of several small-molecule crystals in polymers were measured for the first time near the glass transition temperature, including d-mannitol (β polymorph) in PVP, indomethacin (γ polymorph) in PVP/VA, and nifedipine (α polymorph) in PVP/VA. A DSC method was developed for measuring the solubility of crystalline drugs in polymers. Cryomilling the components prior to DSC analysis improved the uniformity of the mixtures and facilitated the determination of dissolution endpoints. This method has the potential of providing useful data for designing physically stable formulations of amorphous drugs.
184 citations
TL;DR: Dodecyl amine-modified graphene (DA-G)/linear low density polyethylene (LLDPE) nanocomposites were prepared through solution mixing in this article.
184 citations
TL;DR: In this paper, the effects of biodegradable plasticizers on the thermal and mechanical properties of poly (3-hydroxybutyrate-co-3hydroxyvalerate) (PHBV) were studied using thermal and physical analyses.
184 citations
TL;DR: Graphene sheets were produced from graphite oxide using a simple two-step process as mentioned in this paper, in which the mix is heated in an inert gas environment (e.g. N2) for a very short time to a moderate temperature (ca. 600°C). Reaction temperature selection should be consistent with the decomposition temperature of the expansion-reduction agent.
184 citations