Disciform macular scar

About: Disciform macular scar is a research topic. Over the lifetime, 6 publications have been published within this topic receiving 69 citations.

Subretinal neovascularization in the Vogt-Koyanagi-Harada syndrome.

Abstract: Two Hispanic patients with Vogt-Koyanagi-Harada (VKH) syndrome each developed a disciform lesion involving the macula of one eye several months after the onset of symptoms. Each had extraocular manifestations which included pleocytosis of the cerebrospinal fluid. The disciform lesions were associated with retinochoroidal anastomoses, a finding not previously reported in VKH syndrome. Each patient had a separate extramacular disciform lesion in the same eye. Two other Hispanic patients with diffuse bilateral intraocular inflammation had ocular findings consistent with VKH syndrome. One of these patients developed bilateral peripapillary disciform lesions and the other developed a disciform macular scar in one eye. Fluorescein angiography in each patient showed early irregular hyperfluorescence with late intense staining. The disciform detachments occurred in areas of reactive proliferation of the retinal pigment epithelium, and we postulate that growth of subretinal new vessels occurred through areas of Bruch's membrane that were damaged by the inflammation.

[Sorsby's pseudo-inflammatory macular dystrophy: laser treatment]

Abstract: In 1949, Sorsby described a familial fundus disease with progressive visual loss and bilateral hemorrhages and exudates of the posterior pole. The dystrophy, whose inheritance was apparently autosomal dominant, was called pseudo-inflammatory macular dystrophy because of extensive macular lesions that could suggest a post-inflammatory change. The ophthalmoscopic signs include the presence of diffuse drusen-like deposits with extensive changes of retinal pigment epithelium and focal atrophy of the choriocapillaris, particularly in the posterior pole. Some eyes grow subretinal neovascularization, which appears associated to retinal edema, deep hemorrhages and hard exudates. These cases ultimately result in a disciform macular scar. Atrophy of peripheral fundus is typical of advanced stages. We present the case of three sisters whose fundus lesions resembled Sorsby's pseudo-inflammatory macular dystrophy. In two of them, where there was a great suspicion of macular subretinal neovascularization, the laser treatment seemed to positively condition the course of the disease. In our opinion, even though a generalized atrophy of the choroid and retina cannot probably be avoidable, laser treatment can delay the loss of central vision, by blocking the capillaries from leaking, thus preventing secondary destruction from bleeding and fibrosis.

Choroidal neovascularization and angioid streaks in pseudoxanthoma elasticum.

Abstract: Aim To report a case of pseudoxanthoma elasticum (PXE) in a 48 year old woman that presented with bilateral blurry vision Methods A case report Results A 48-year-old woman presented with bilateral blurry vision and right eye metamorphopsia The patient had a history of angioid streaks in the left eye ten years ago for which she had received laser surgery and had poor residual vision Visual acuity was 20/60 in the right eye and count fingers at 6 feet in the left Fundus examination showed subretinal hemorrhage and macular thickening on the right and a disciform macular scar with focal atrophic pigment epithelial lesions on the left Both eyes had angioid streaks and peau d'orange pigmentary pattern of the retina External examination showed several, yellow skin papules and plaques on the lateral and posterior neck, as well as prominent mental creases Pathologic examination of skin biopsy confirmed the diagnosis of PXE, showing calcium deposition and fragmented, clumped elastic fibers in the deep reticular dermis She responded well to intravitreal bevacizumab injections and visual acuity improved to 20/25 OD Preventative care was emphasized and the patient was referred to cardiology, gastroenterology and human genetics for counseling Conclusion PXE is a multisystem disorder affecting the dermatologic, ocular, and cardiovascular systems Ophthalmic findings of angioid streaks and choroidal neovascularization in the presence of stereotypical skin changes and prominent mental creases should prompt evaluation for PXE