Topic
DMC1
About: DMC1 is a research topic. Over the lifetime, 321 publications have been published within this topic receiving 25826 citations.
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TL;DR: These findings strongly implicate Spo11 as the catalytic subunit of the meiotic DNA cleavage activity and provide direct evidence that the mechanism of meiotic recombination initiation is evolutionarily conserved.
1,727 citations
TL;DR: It is suggested that the Rad51 protein, probably together with Rad52 protein, is involved in a step to convert DSBs to the next intermediate in recombination.
1,227 citations
TL;DR: The current article reviews recent information on diverse aspects of chromosome morphogenesis, notably relationships between sisters, development of axial structure, and variations in chromatin status in an historical context.
Abstract: ▪ Abstract Meiotic chromosomes have been studied for many years, in part because of the fundamental life processes they represent, but also because meiosis involves the formation of homolog pairs, ...
1,206 citations
TL;DR: DMC1 phenotypes provide further evidence that recombination and SC formation are interrelated processes and are consistent with a requirement for DNA-DNA interactions during SC formation, and additional evidence suggests that arrest occurs at a meiosis-specific cell cycle "checkpoint" in response to a primary defect in prophase chromosome metabolism.
1,142 citations
TL;DR: The Spo11 protein initiates meiotic recombination by generating DNA double-strand breaks (DSBs) and is required for meiotic synapsis in S. cerevisiae, but it is speculated that there is an additional role for Spo11, after it generates DSBs, insynapsis.
727 citations