Showing papers on "Docosahexaenoic acid published in 1975"
TL;DR: The phospholipid class and fatty acid composition of photoreceptor membranes, mitochondria, microsomes and nuclei of bovine retina are reported and phosphatidyl serine is the major polyunsaturate in all lipid classes except phosphorus inositol, where arachidonic acid predominates.
64 citations
TL;DR: Testes removed at autopsy from humans aged 19-53 had lipid and fatty acid compositions not significantly different from the older age group, and Histological examination revealed some, but not complete, correlation between the fatty acid composition and the state of the germinal epithelium.
Abstract: Lipid and fatty acid composition of testes removed at autopsy from humans aged 56-89 years was found to be similar to that of testes obtained at orchiectomy from humans of the same age group. It is suggested, therefore, that the use of autopsy specimens for this type of study is valid. Testes removed at autopsy from humans aged 19-53 had lipid and fatty acid compositions not significantly different from the older age group. Histological examination revealed some, but not complete, correlation between the fatty acid composition and the state of the germinal epithelium. Immature testes of infants had an altered lipid composition compared to adult tissue, particularly with reference to lower content of the polyenoic acids. 5.8. II eicosatrienoic and 4.7. 10. 13. 16. 19 docosahexaenoic acids. In two specimens of undescended testicles removed from young adults, the tissues were observed to be atrophied and were found to have decreased concentrations of 5, 8. Il eicosatrienoic and 4, 7, 10. 13. 16. 19 docosahexuenoic acids. It is suggested that there is a relationship between these two polyenes and the development of the germinal cells of human tissue.
29 citations
01 Jan 1975
TL;DR: A study was made to elucidate fatty acid composition of Anchoviella and Thrissocleus, and bring to light similarities with other clupeids.
Abstract: A study was made to elucidate fatty acid composition of Anchoviella and Thrissocleus, and bring to light similarities with other clupeids. The results are tabulated. The polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid, are the 2 major fatty acids in the phospholipid fraction of both fish. Myristic, palmitic and stearic acids are the major components of the nonphosphorylated fraction.
2 citations
TL;DR: DNA synthesis at 21-22h was inhibited; the effect was maximal when the drugs were administered at 18 h, confirming the previous observations of an a-adrenergic facilitation of DNA synthesis during the late S phase.
Abstract: during the S phase is shown in Table 1. DNA synthesis at 21-22h was inhibited; the effect was maximal when the drugs were administered at 18 h. This confirms the previous observations (Thrower & Ord, 1974a,b) of an a-adrenergic facilitation of DNA synthesis during the late S phase. The time-course of incorporation of [jHIthymidine into liver DNA after administration of phenoxybenzamine at 18h is shown in Fig. l(6). DNA synthesis at 21-22 h is decreased, and the amount of r3H]thymidine incorporated into DNA during the whole wave appears to be decreased. Table 1 compares the effects of aand 8-adrenergic-blocking drugs, administered at 18 h, on DNA synthesis and cyclic AMP production at 21-22h. As expected, phenoxy benzamine did not inhibit the increase in cyclic AMP production, since catecholamines act at 8-adrenergic sites to stimulate liver adenylate cyclase. However, the 8-blockers propranolol (lOmg/kg) and pindolol (LB 46; 5mg/kg) failed to inhibit the increase in cyclic AMP concentration; DNA synthesis at 21-22h was also unaffected by propran0101. Both aand 8-blockers, administered at 18h, caused an increased in ornithine decarboxylase activity at 21 h (control animals 195 k 68pmol of 14C02/20min per mg of protein; phenoxybenzamine-treated animals, 320 k 102; pindolol-treated animals, 340 k 14. It is clear that, at this time, 18-22h after the operation, the hormonal control of these parameters differs from that observed for the changes at M h and at 12-13 h (Thrower et al., 1973; Thrower & Ord, 1974u,b). Catecholamines still play an important role at this time, facilitating DNA synthesis in the replicating hepatocytes via a-adrenergic receptors. The increases in cyclic AMP concentration and ornithine decarboxylase activity appear to be co-ordinate, but are not regulated by catecholamines; the observed changes could be accounted for in terms of increased glucagon secretion activating liver adenylate cyclase, or decreased insulin secretion decreasing liver cyclic AMP phosphodiesterase activity: the increased concentration of cyclic AMP would also result in increased ornithine decarboxylase activity (Beck et al., 1972). The role of the increase in cyclic AMP production after 19h remains unclear. It is possible that this increase may have a function in regulating the wave of DNA synthesis, although the previous waves of cyclic AMP production at 4h and 12-13 h after partial hepatectomy do not appear to serve such a function (Thrower & Ord, 1974~).
1 citations