Docosenoic Acid

About: Docosenoic Acid is a research topic. Over the lifetime, 64 publications have been published within this topic receiving 1383 citations.

Monounsaturated fatty acids and perhydrocyclopentanophenanthrene nucleus combination molecules, and their precursors, and the use of all of these as weight-loss agents

Abstract: The pharmaceutical and/or cosmetic compositions for treatment of obesity and/or overweight contain an effective amount of a fatty-acid monoester of a 2 hydroxy derivative estrogen and a fatty acid wherein the estrogen is preferably a 2 hydroxy derivative of estrone, diethylstilbestrol, estriol, estradiol or ethinyl estradiol and the fatty acid is selected from the group consisting of the fatty acid oleic acid, arachadonic, palmitic, palmitoleic, linoleic, linolenic, cis 13 docosenoic acid, and the fatty acid, cis 15 tetracosenoic acid eicosenoic acid, especially cis 11 eicosenoic, although cis 5, cis 8, and cis 13 eicosenoic acid are also effective. The C-22 fatty acid monoester of estrogen, cis 13 docosenoic acid (Erucic acid), and the C-24 fatty acid monoester of estrogen, cis 15 tetracosenoic acid (Nervonic acid) are also effective and are included in this disclosure. In addition, synthesized combination molecules formed when a monounsaturated fatty acid of 20 carbon atoms or more is joined via an ester, ether, or amide bond to either a steroid or any molecule containing a perhydrocyclopentanophenanthrene nucleus or perhydrocyclopentanophenanthrene nucleus derivative are also included in this invention. The fatty-acid monoesters mimic the function of estrone monooleate, as a signal that informs the brain of the size of fat tissue mass. In preferred pharmaceutical and/or cosmetic compositions for intravenous injection the monoester is incorporated in a lipidic suspension, prepared from lipoproteins or from liposome components, such as soy oil and egg phospholipids. When administered to rats with a 15% of total adipose tissue, they produce weight reduction of about 10%, by a new and unexpected mechanism. They are useful for the treatment of obesity and/or overweight in mammals, with the advantages of high efficacy and low toxicity.

Uses of unsaturated fatty acids for inhibiting virus replication and /or infection

Abstract: Uses of unsaturated fatty acid linoleic acid and docosenoic acid or pharmaceutically acceptable salts or esters thereof for inhibiting hepatitis C virus replication or preventing and/or treating hepatitis C virus inflection are disclosed.

Long-term exposure to docosenoic acids in animals: absence of myocardial lesions in harp seals (pagophilus groenlandicus) and grey seals (halichoerus grypus)

Abstract: Hearts were collected from 46 harp or grey seals of various ages and sexes After fixation in formalin, sections were cut and stained with hematoxylin-eosin, and in a limited number of cases with Oil-Red-0 Histopathological examination revealed the presence of non-specific myocarditis in two instances only and no lipid deposits The percentage of docosenoic acid (primarily 22:1ω11) in blubber and heart muscle triglyceride, tabulated for grey seal dam-pup pairs is evidence of exposure from birth These results indicate that the susceptibility of the rat myocardium to docosenoic acids may not be as broadly relevant in other species such as the seal, pig and man as has been proposed