Showing papers on "Dosage compensation published in 1967"
Book•
01 Jan 1967
TL;DR: Evidence is provided that the X and the Y or the Z and the W were Originally an Homologous Pair of Ordinary Chromosomes, and the Conservation of the Original X or Z.
Abstract: I Evolution of Vertebrate Sex Chromosomes and Genomes- 1 Evidence Indicating that the X and the Y or the Z and the W were Originally an Homologous Pair of Ordinary Chromosomes- 2 Differentiation of the Primitive Sex Elements at the Expense of the Y or W, and the Conservation of the Original X or Z- 3 Polyphyletic Evolution of Vertebrates- 4 Conservation of the Original X and Homology of the X-linked Genes in Placental Mammals- 5 Conservation of the Original Z-Chromosome by Diverse Avian Species and Homology of the Z-linked Genes- II Evolution of Dosage Compensation Mechanism for Sex-linked Genes- 6 The Basic Difference in Constitution between the Mammalian X and the Drosophila X- 7 The Two Different Means of Achieving Dosage Compensation for X-linked Genes Employed by Drosophila and Mammals- 8 Various Consequences of the Dosage Compensation by X-inactivation- 9 The Conservation of the Original X and Dosage Compensation in the Face of X-polysomy- 10 Three Different Consequences of X-autosome Translocation- 11 The Consequences of Y-autosome Translocation and the XO as the Normal Female of Certain Mammalian Species- 12 Apparent Absence of Dosage Compensation for Z-linked Genes of Avian Species- III On So-called Sex Determining Factors and the Act of Sex Determination- 13 Elucidation of So-called Sex-determining Factors- 14 Time and Place of Action of Sex-determining Factors in Ontogeny- Author Index
363 citations
TL;DR: The extreme puffing of the whole X of the male is further evidence that dosage compensation in Diptera is brought about by increasing the activity of loci throughout the single X chromosome of themale.
20 citations
TL;DR: It is shown that neither the behaviour of double heterozygotes for sex-linked genes nor that of X-autosome translocations provides independent evidence in favour of the Lyon hypothesis, which requires the assumption that partial inhibition of gene action happens in both X-chromosomes of mouse females, and presumably the females of other mammals.
Abstract: Contrary to opinions expressed by various authors, the phenotype of heterozygotes for mammalian sex-linked genes gives no support for the Lyon hypothesis (L.H.). Evidence, mainly from the mouse, shows that in such heterozygotes, both alleles act together as in autosomal genes.In the present paper, it is shown that neither the behaviour of double heterozygotes for sex-linked genes nor that of X-autosome translocations provides independent evidence in favour of the L.H.: in each case, the interpretation depends on that of the behaviour of single heterozygotes and hence fails to discriminate. Moreover, new facts from both types of situation are also contrary to the L.H. In particular, a unified interpretation which fits the behaviour of genes in all known types of X-autosome translocations in the mouse requires the assumption that partial inhibition of gene action happens in both X-chromosomes of mouse females, and presumably the females of other mammals. The new hypothesis is consistent with all relevant genetical facts and, like the L.H., it also accounts for dosage compensation.
18 citations