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Dosage form

About: Dosage form is a research topic. Over the lifetime, 13486 publications have been published within this topic receiving 331654 citations. The topic is also known as: unit doses & dosage forms.

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Journal ArticleDOI
TL;DR: Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).

4,794 citations

01 Apr 1990
TL;DR: The principles of dosage form design and development and novel and advanced dosage forms, delivery systems, and devices: radiopharmaceuticals products of biotechnology novel dosage forms and drug delivery technology are introduced.
Abstract: Section 1 Principles of dosage form design and development: introduction to drugs and pharmacy new drug development and approval process dosage form design - pharmaceutic and formulation consideration dosage form design - biopharmaceutic and pharmacokinetics considerations current good manufacturing practices and good compounding practices. Section 2 Solid dosage forms and modified-release drug delivery systems: powders and granules capsules and tables modified-release dosage forms and drug delivery systems. section 3 Semi-solid and transdermal systems: ointments, creams, and gels transdermal drug delivery systems, Section 4 Pharmaceutical inserts: suppositories and inserts. Section 5 Liquid dosage forms: solutions disperse systems. Section 6 Sterile dosage forms and delivery systems: parenteral biological ophthalmic solutions and suspensions. Section 7 Novel and advanced dosage forms, delivery systems, and devices: radiopharmaceuticals products of biotechnology novel dosage forms and drug delivery technology. Appendix: systems and techniques of pharmaceutical measurement.

2,235 citations

01 Jan 2002
TL;DR: The design of dosage forms, principles of sterilization practice, and the operation of clean rooms are described, which will help clarify the role of bioavailability in drug delivery.
Abstract: Design of dosage forms. PART ONE SCIENTIFIC PRINICIPLES OF FORMULATION SCIENCE Solutions and their properties. Rheology and flow. Surface and interfacial phenomena. Solubility and dissolution rate. Disperse systems. Kinetics and product stability. PART TWO PARTICLE SCIENCE AND POWDER TECHNOLOGY Solid-state properties of powders. Particle size analysis. Particle size reduction. Particle size separation. Mixing. Powder flow. PART THREE BIOPHARMACEUTICS PRINCIPLES OF DRUG DELIVERY Introduction to Biopharmaceutics. Factors influencing bioavailability. Assessment of bioavailability. Dosage Regimens. Sustained and extended release. PART FOUR DOSAGE FORM DESIGN AND MANUFACTURE Preformulation. Solutions, Suspensions and Emulsions. Filtration. Powders and granules. Granulation. Drying. Tablets and compaction. Tablet coating. Capsules and encapsulation. Pulmonary drug delivery. Nasal delivery. Rectal and vaginal delivery. Parenteral products. Transdermal drug delivery. Delivery of proteins/biotech products. Packs and packaging. Materials of fabrication and corrosion. Heat transfer and the properties of steam. PART FIVE PHARMACEUTICAL MICROBIOLOGY AND STERILIZATION Fundamentals of microbiology. The action of physical and chemical agents on micro-organisms. Microbiological contamination and preservation. Principles of sterilization. Sterilization practice. Design and operation of clean rooms.

2,069 citations

Journal ArticleDOI
28 Aug 1997-Nature
TL;DR: The synthesis of a thermosensitive, biodegradable hydrogel consisting of blocks of poly(ethylene oxide) and poly(L-lactic acid) and aqueous solutions of these copolymers exhibit temperature-dependent reversible gel–sol transitions.
Abstract: Polymers that display a physicochemical response to stimuli are widely explored as potential drug-delivery systems. Stimuli studied to date include chemical substances and changes in temperature, pH and electric field. Homopolymers or copolymers of N-isopropylacrylamide and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (known as poloxamers) are typical examples of thermosensitive polymers, but their use in drug delivery is problematic because they are toxic and non-biodegradable. Biodegradable polymers used for drug delivery to date have mostly been in the form of injectable microspheres or implant systems, which require complicated fabrication processes using organic solvents. Such systems have the disadvantage that the use of organic solvents can cause denaturation when protein drugs are to be encapsulated. Furthermore, the solid form requires surgical insertion, which often results in tissue irritation and damage. Here we report the synthesis of a thermosensitive, biodegradable hydrogel consisting of blocks of poly(ethylene oxide) and poly(L-lactic acid). Aqueous solutions of these copolymers exhibit temperature-dependent reversible gel-sol transitions. The hydrogel can be loaded with bioactive molecules in an aqueous phase at an elevated temperature (around 45 degrees C), where they form a sol. In this form, the polymer is injectable. On subcutaneous injection and subsequent rapid cooling to body temperature, the loaded copolymer forms a gel that can act as a sustained-release matrix for drugs.

1,930 citations

Journal ArticleDOI
TL;DR: This review highlights the use of hydrogels (a class of polymeric systems) in controlled drug delivery, and their application in stimuli- responsive, especially pH-responsive, drug release.

1,593 citations

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No. of papers in the topic in previous years