Showing papers on "Drug carrier published in 1980"
TL;DR: The liposomal encapsulation favourably altered the drug dipposition; the concentration of the drug decreased at the site of its adverse effects and increased at the sites where its activity is desired.
497 citations
TL;DR: Polyalkylcyanoacrylate nanoparticles seem to be an interesting drug carrier owing to their size, structure, degradability, and drug sorptive properties.
157 citations
144 citations
TL;DR: The data show that, for small unilamellar neutral liposomes, the halflife of their solute content in the circulation of mice can be controlled by the appropriate choice of the phospholipid component and the addition of excess cholesterol or its omission.
134 citations
TL;DR: Preliminary results of experimental chemotherapy using actinomycin D loaded polymethylcyanoacrylate nanoparticles on the growth of a transplantable soft tissue sarcoma of the rat indicate that the use of poly methylcyanoacanine nanoparticles as a drug carrier enhances the activity of the drug towards the subcutaneous Sarcoma.
129 citations
114 citations
TL;DR: Electron-micrographs of thymocytes subjected to field pulses of various strengths and durations show that the pulse length is a critical factor for the reversibility of the field induced effects in the cell.
99 citations
40 citations
TL;DR: After intravenous injection in mice, magnetic microspheres localized in the site (lung) at which two permanent magnets were placed, suggesting that magnetic albumin microsphere could become effective drug carriers with site specificity for the delivery of chemotherapeutic agents in cancer therapy.
Abstract: Magnetic guidance of magnetic albumin microsphere for site specific drug delivery was investigated in vivo. After intravenous injection in mice, magnetic microspheres localized in the site (lung) at which two permanent magnets were placed. Injection into the renal artery in rats also indicated that the microspheres were concentrated at the kidney by a magnetic field. When magnet was not applied, however, the microspheres were concentrated mainly in the liver. Such preferential localization by magnetic means suggested that magnetic albumin microspheres could become effective drug carriers with site specificity for the delivery of chemotherapeutic agents in cancer therapy.
36 citations
34 citations
TL;DR: Mouse thymocytes and erythrocytes are loaded electrically with drugs in isotonic solution for targeting the drugs to specific sites in the organism in order to achieve a controlled drug release in time and space.
Abstract: Mouse thymocytes and erythrocytes are loaded electrically with drugs in isotonic solution The loaded cells are used for targeting the drugs to specific sites in the organism in order to achieve a controlled drug release in time and space The field technique used for the loading of the cells is based on the dielectric breakdown of the cell membrane which is observed when cell suspensions are subjected to external field pulses of 2–20 kV/cm for short time intervals (ns to μ8) When an apparent membrane potential of about 1 V is reached in response to the external field, the membrane breaks down reversibly The breakdown of the membrane is associated with a remarkable and reversible permeability increase of the cell membrane The increase in permeability depends on the strength and the duration of the field pulse
TL;DR: Magnetically responsive drug-bearing microspheres fulfill all of the desired properties of an ideal drug carrier as mentioned in this paper, and the present system allows for retention of injected drug at the target site.
Patent•
17 Nov 1980
TL;DR: In this article, the controlled release administration of a biologically active compound to an animal, comprising of a combination of the biological active compound and hydroxyalkyl starch, is described.
Abstract: Composition for the controlled release administration of a biologically active compound to an animal, comprising a combination of the biologically active compound and hydroxyalkyl starch.