Showing papers on "Drug carrier published in 2001"
Journal Article•
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Abstract: The rapid recognition of intravenously injected colloidal carriers, such as liposomes and polymeric nanospheres from the blood by Kupffer cells, has initiated a surge of development for "Kupffer cell-evading" or long-circulating particles. Such carriers have applications in vascular drug delivery and release, site-specific targeting (passive as well as active targeting), as well as transfusion medicine. In this article we have critically reviewed and assessed the rational approaches in the design as well as the biological performance of such constructs. For engineering and design of long-circulating carriers, we have taken a lead from nature. Here, we have explored the surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition. Our analysis is then centered where such strategies have been translated and fabricated to design a wide range of particulate carriers (e.g., nanospheres, liposomes, micelles, oil-in-water emulsions) with prolonged circulation and/or target specificity. With regard to the targeting issues, attention is particularly focused on the importance of physiological barriers and disease states.
3,413 citations
TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.
3,284 citations
TL;DR: In this paper, a new application of MCM-41 mesoporous materials has been developed, where two kinds of surfactants, C16TAB and C12TAB, have been employed to get different pore sizes.
Abstract: A new application of MCM-41 mesoporous materials has been developed. Two kinds of surfactants, C16TAB and C12TAB, have been employed to get different pore sizes. The samples were disk-shaped conformed before and after charging with ibuprofen, an anti-inflammatory drug. In all the cases the weight percent ratio of drug/MCM-41 was 30%. The drug release plots show a different behavior depending on the method for charging the drug in the material but not on the employed surfactant.
1,955 citations
TL;DR: The review concentrates on the use of polymeric micelles as pharmaceutical carriers and the basic mechanisms underlying micelle longevity and steric protection in vivo are considered with a special emphasis on long circulating drug delivery systems.
1,670 citations
TL;DR: Two approaches to further improve the effectiveness of amphiphilic block copolymer-based drug delivery systems are discussed and the feasibility of channel proteins and metal (nano)particles to improve temporal control over the drug release process is discussed.
1,273 citations
TL;DR: The chitosan-DNA nanoparticles could partially protect the encapsulated plasmid DNA from nuclease degradation as shown by electrophoretic mobility analysis and three different schemes to conjugate transferrin or KNOB protein to the nanoparticle surface were developed.
1,201 citations
TL;DR: This review considers drug-vehicle interactions and the role of vesicles and particles and of particular interest is the synergy between chemical enhancers, ultrasound, iontophoresis and electroporation.
1,143 citations
TL;DR: Intravenously injected doxorubicin-loaded polysorbate 80-coated nanoparticles were able to lead to a 40% cure in rats with intracranially transplanted glioblastomas 101/8, and may be especially helpful for the treatment of the disseminated and very aggressive brain tumors.
1,073 citations
TL;DR: Detailed refinements of biomembrane sensors and liposome delivery systems that are effective in the presence of other membrane-bound proteins in vivo may permit selective delivery of therapeutic compounds to selected intracellular target areas.
880 citations
TL;DR: A large number of polysaccharides have already been studied for their potential as colon-specific drug carrier systems, such as chitosan, pectin, chondroitin sulphate, cyclodextrin, dextrans, guar gum, inulin, amylose and locust bean gum.
822 citations
TL;DR: It is demonstrated that relatively large drug carriers, such as 200-nm liposomes, can also be delivered into cells by TAT peptide attached to the liposome surface, confirming the energy-independent character of this process.
Abstract: To achieve an efficient intracellular drug and DNA delivery, attempts were made to target microparticulate drug carriers into cytoplasm bypassing the endocytotic pathway. TAT peptides derived from the HIV-1 TAT protein facilitate intracellular delivery of proteins and small colloidal particles. We demonstrated that relatively large drug carriers, such as 200-nm liposomes, can also be delivered into cells by TAT peptide attached to the liposome surface. Liposomes were fluorescently labeled with membranotropic rhodamine-phosphatidylethanolamine or by entrapping FITC-dextran. Incubation of fluorescent TAT liposomes with mouse Lewis lung carcinoma cells, human breast tumor BT20 cells, and rat cardiac myocyte H9C2 results in intracellular localization of certain liposomes. Steric hindrances for TAT peptide⋅cell interaction (attachment of TAT directly to the liposome surface without spacer or the presence of a high MW polyethylene glycol on the liposome surface) abolish liposome internalization, evidencing the importance of direct contact of TAT peptide with the cell surface. Low temperature or metabolic inhibitors, sodium azide or iodoacetamide, have little influence on the translocation of TAT liposomes into cells, confirming the energy-independent character of this process. The approach may have important implications for drug delivery directly into cell cytoplasm.
TL;DR: Preliminary studies showed the feasibility of chitosan nanoparticles to entrap the basic drug DOX and to deliver it into the cells in its active form.
TL;DR: An introduction into mathematical modeling approaches of bioerodible controlled drug delivery systems and to present the most important erosion theories reported in the literature are given.
TL;DR: It is concluded that CS nanoparticles may represent an interesting vehicle in order to enhance the therapeutic index of clinically challenging drugs with potential application at extraocular level.
TL;DR: Hydrogels that can respond to a variety of physical, chemical and biological stimuli hold enormous potential for design of closed-loop drug-delivery systems.
TL;DR: The results suggest that encapsulation of the conjugate in nanoparticles not only reduces the side effects, but also improves its therapeutic efficacy in the treatment of solid tumors.
TL;DR: Biodegradability, phase behavior, ability to deliver drugs of varying sizes and polarity and the ability to enhance the chemical and/or physical stability of incorporated drugs and proteins make the cubic phase gel an excellent candidate for use as a drug delivery matrix.
TL;DR: ReGel's inherent ability to solubilize (400 to >2000-fold) and stabilize poorly soluble and sensitive drugs, including proteins is a substantial benefit and the gel provided excellent control of the release of paclitaxel for approximately 50 days.
TL;DR: The result of pre-clinical study of NK911, a polymeric micelle carrier system for doxorubicin (DOX) shows much stronger activity than the free DOX, which can entrap the sufficient amount of DOX in tumor tissue by EPR effect.
TL;DR: PEGylated poly(lactic-co-glycolic acid) (PEG-PLGA) nanoparticles could be an effective carrier for PPD delivery and obviously change the protein biodistribution in rats compared with that of PLGA nanoparticles.
TL;DR: F fluorinated lipids and fluorinated surfactants can be used to elaborate and stabilize various colloidal systems, including different types of emulsions, vesicles and tubules that also show promise for controlled release drug delivery.
TL;DR: The cytotoxic activity of the micelles against HepG2 cells was greater than free doxorubicin, suggesting that the miceLLes containing conjugated doxorbicin were more effectively taken up cellularly, by an endocytosis mechanism rather than by passive diffusion.
TL;DR: The use of submicron-sized carriers holds promise for the targeted delivery of drugs to the inflamed colonic mucosal areas in inflammatory bowel disease.
Abstract: Purpose. The size-dependent deposition of microparticles and nanoparticles after oral administration to rats using an experimental model colitis was examined. Local delivery of an entrapped drug could reduce side effects and would be a distinct improvement compared with existing colon delivery devices.
TL;DR: From the studies reviewed it is concluded that chitosan and chitOSan derivatives are promising polymeric excipients for mucosal drug and vaccine delivery.
TL;DR: It appears that cyclodextrins can only enhance topical drug delivery in the presence of water.
TL;DR: It is demonstrated that a surface-modulated PEG-PDLLA micelle with a suitable size and a narrowly distributed nature has promising potential as a long-circulating carrier system with desirable biocompatibility and biofunctionality.
TL;DR: PEGylated poly (cyanoacrylate) nanoparticles are proposed as a new brain delivery system and two requirements to design adequate delivery systems for such a purpose are highlighted: a) long-circulating properties of the carrier, and b) appropriate surface characteristics to allow interactions with BBB endothelial cells.
Abstract: Purpose. The aim of this study was to evaluate the ability of long-circulating PEGylated cyanoacrylate nanoparticles to diffuse into the brain tissue.
TL;DR: A novel formulation process that utilizes an ionizable aminolipid and an ethanol-containing buffer system for encapsulating large quantities of polyanionic ODN in lipid vesicles and forms 'stabilized antisense-lipid particles' (SALP), which is believed to represent a viable candidate for systemic applications involving nucleic acid therapeutics.
TL;DR: It is found that dipalmitoyl-phosphatidylcholine (DPPC) can provide more complete coating on the surface of the products which thus results in a higher emulsifying efficiency compared with polyvinyl alcohol (PVA).
TL;DR: Co-administrations of TMC with peptide drugs were found to substantially increase the bioavailability of the peptide in both rats and juvenile pigs compared with administrations without the polymer.