Topic
Drug carrier
About: Drug carrier is a research topic. Over the lifetime, 18276 publications have been published within this topic receiving 997718 citations. The topic is also known as: drug carriers & drug vehicle.
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TL;DR: The result indicates that the rates of drug release and biodegradation could be tailored by adjusting polymer composition, which might be used as a drug carrier in medical applications.
Abstract: Polylactide (PLA)-poly(ethylene glycol) (PEG) copolymers were synthesized from polyethylene glycol and D,L-lactide using low toxic stannous octoate as catalyst at 180°C by bulk polymerization. The copolymers were characterized by GPC, IR, and 13C-NMR. A full assignment NMR spectrum is presented. The physical, drug release, and biodegradable properties in vitro of PLA–PEG copolymers were investigated. The result indicates that the rates of drug release and biodegradation could be tailored by adjusting polymer composition. This amorphous material might be used as a drug carrier in medical applications.
304 citations
TL;DR: An overview of the potential of chitosan‐based systems for improving the retention and biodistribution of drugs applied topically onto the eye and the tolerance, toxicity and biodegradation of the carriers under evaluation were reviewed.
Abstract: This paper presents an overview of the potential of chitosan-based systems for improving the retention and biodistribution of drugs applied topically onto the eye. Besides its low toxicity and good ocular tolerance, chitosan exhibits favourable biological behaviour, such as bioadhesion- and permeability-enhancing properties, and also interesting physico-chemical characteristics, which make it a unique material for the design of ocular drug delivery vehicles. The review summarizes the techniques for the production of chitosan gels, chitosan-coated colloidal systems and chitosan nanoparticles, and describes their mechanism of action upon contact with the ocular mucosa. The results reported until now have provided evidence of the potential of chitosan gels for enhancing and prolonging the retention of drugs on the eye surface. On the other hand, chitosan-based colloidal systems were found to work as transmucosal drug carriers, either facilitating the transport of drugs to the inner eye (chitosan-coated colloidal systems containing indometacin) or their accumulation into the corneal/conjunctival epithelia (chitosan nanoparticles containing ciclosporin). Finally, the tolerance, toxicity and biodegradation of the carriers under evaluation were reviewed.
304 citations
TL;DR: Results indicate that ionically cross-linked chitosan beads may be useful in stomach specific drug delivery and had a good shape, but also improved pH-responsive drug release properties.
304 citations
TL;DR: This review focuses on the current application of polyester-based micelles and nanoparticles to the tumour targeting of taxanes.
304 citations
TL;DR: In this article, an on-off release of sodium fluorescein over multiple magnetic cycles has been successfully demonstrated using prototype membrane-based devices and the total drug dose delivered was directly proportional to the duration of the “on” pulse.
Abstract: Nanocomposite membranes based on thermosensitive, poly(N-isopropylacrylamide)-based nanogels and magnetite nanoparticles have been designed to achieve “on-demand” drug delivery upon the application of an oscillating magnetic field. On−off release of sodium fluorescein over multiple magnetic cycles has been successfully demonstrated using prototype membrane-based devices. The total drug dose delivered was directly proportional to the duration of the “on” pulse. The membranes were noncytotoxic, were biocompatible, and retained their switchable flux properties after 45 days of subcutaneous implantation.
303 citations