Topic
Drug carrier
About: Drug carrier is a research topic. Over the lifetime, 18276 publications have been published within this topic receiving 997718 citations. The topic is also known as: drug carriers & drug vehicle.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: This review explores the current methods that use high pressure and scCO(2) for the production of drug delivery systems and the more specialized application of the fluid in the formation of highly porous tissue engineering scaffolds.
274 citations
••
TL;DR: The use of colloidal, particulate carrier systems (25 nm to 1 µm in diameter) in colloidal drug carriers used to improve the therapeutic index of both established and new drugs is discussed.
273 citations
••
TL;DR: The selected solvents used to prepare micelles by dialysis in water affect the size of polymeric micelle, and an increase of molecular weight and hydrophobic components of diblock copolymer produced larger micells.
273 citations
••
TL;DR: The physical state of the liposome encapsulated anticancer drug Doxorubicin is investigated, showing that upon encapsulation the drug molecules form a gel‐like phase.
273 citations
••
TL;DR: The barriers that decrease the bioavailability of an ophthalmic drug; the objectives to be considered in producing optimal formulations; and the approaches being used to improve the corneal penetration of a drug molecule and delay its elimination from the eye are reviewed.
Abstract: The main aim of pharmacotherapeutics is the attainment of an effective drug concentration at the intended site of action for a sufficient period of time to elicit the response. A major problem being faced in ocular therapeutics is the attainment of an optimal concentration at the site of action. Poor bioavailability of drugs from ocular dosage forms is mainly due to the tear production, non-productive absorption, transient residence time, and impermeability of corneal epithelium. This article reviews: the barriers that decrease the bioavailability of an ophthalmic drug; the objectives to be considered in producing optimal formulations; and the approaches being used to improve the corneal penetration of a drug molecule and delay its elimination from the eye. The focus of this review is on the recent developments in topical ocular drug delivery systems, the rationale for their use, their drug release mechanism, and the characteristic advantages and limitations of each system. In addition, the review...
273 citations