Topic
Drug carrier
About: Drug carrier is a research topic. Over the lifetime, 18276 publications have been published within this topic receiving 997718 citations. The topic is also known as: drug carriers & drug vehicle.
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TL;DR: This review provides a survey and analysis of the processes determining the release rate, and the various mechanisms of drug release that have been reported in the literature are analyzed in this review.
1,029 citations
TL;DR: A tailor-made dual pH-sensitive polymer-drug conjugate nanoparticulate system has showed enhanced cytotoxicity in drug-resistant cancer stem cells, indicating its great potential for cancer therapy.
Abstract: Efficient delivery of therapeutics into tumor cells to increase the intracellular drug concentration is a major challenge for cancer therapy due to drug resistance and inefficient cellular uptake Herein, we have designed a tailor-made dual pH-sensitive polymer–drug conjugate nanoparticulate system to overcome the challenges The nanoparticle is capable of reversing its surface charge from negative to positive at tumor extracellular pH (∼68) to facilitate cell internalization Subsequently, the significantly increased acidity in subcellular compartments such as the endosome (∼50) further promotes doxorubicin release from the endocytosed drug carriers This dual pH-sensitive nanoparticle has showed enhanced cytotoxicity in drug-resistant cancer stem cells, indicating its great potential for cancer therapy
1,027 citations
TL;DR: This review is an insight into the exploitation of the various properties of chitosan to microencapsulate drugs and includes the factors that affect the entrapment efficiency and release kinetics of drugs from chitOSan microspheres.
1,016 citations
TL;DR: There is a need for the development of alternate formulation of paclitaxel having good aqueous solubility and at the same time free of any side effects.
1,016 citations
TL;DR: The purpose of this minireview is to provide a concise, yet detailed, introduction to the use of ABCs and polymeric micelles as delivery agents as well as to highlight current and past work in this area.
1,014 citations