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Drug carrier

About: Drug carrier is a research topic. Over the lifetime, 18276 publications have been published within this topic receiving 997718 citations. The topic is also known as: drug carriers & drug vehicle.


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01 Jan 1997

257 citations

Journal ArticleDOI
TL;DR: A new DPPGOG-based liposomal formulation enabling long circulation time combined with fast and efficient drug release under mild hyperthermia is presented, which adds positively to the results with lipid-grafted polyethylenglycol used thus far in temperaturesensitive liposomes and widens the possibilities for clinical applications.
Abstract: Hyperthermia increases the efficiency of various chemotherapeutic drugs and is administered as an adjunct to chemotherapy for the treatment of cancer patients. The temperature-dependent effect can be strongly increased by the use of temperature-sensitive liposomes in combination with regional hyperthermia, which specifically releases the entrapped drug in the heated tumor tissue. The novel lipid 1.2-dipalmitoyl-sn-glycero-3-phosphoglyceroglycerol (DPPGOG), which is closely related to the naturally occurring 1.2-dipalmitoyl-sn-glycero-3-phosphoglycerol, in combination with 1.2-dipalmitoyl-sn-glycero-3-phosphocholine and 1.2-distearoyl-sn-glycero-3-phosphocholine provides long-circulating temperature-sensitive liposomes with favorable properties under mildly hyperthermic conditions (41-42 degrees C). DPPGOG facilitates temperature-triggered drug release from these liposomes (diameter, 175 nm) and leads to a substantially prolonged plasma half-life for the encapsulated drug with t(1/2) = 9.6 h in hamsters and t(1/2) = 5.0 h in rats. Quantitative fluorescence microscopy of amelanotic melanoma grown in the transparent dorsal skin fold chamber of hamsters demonstrated a favorable drug accumulation in heated tissue after i.v. application of these liposomes (42 degrees C for 1 h). The mean area under the curve for tissue drug concentration was increased by more than sixfold by application of the new liposomes compared with nonliposomal drug delivery. In summary, we present a new DPPGOG-based liposomal formulation enabling long circulation time combined with fast and efficient drug release under mild hyperthermia. This adds positively to the results with lipid-grafted polyethylenglycol used thus far in temperature sensitive liposomes and widens the possibilities for clinical applications.

257 citations

Journal ArticleDOI
TL;DR: Transfer of anti‐CD19 into SIL resulted in a three‐fold increase in binding of these liposomes to CD19+ human B cell lymphoma cells.

257 citations

Journal ArticleDOI
TL;DR: In this paper, the authors investigated the influence of process parameters on microsphere morphology and burst release of FD40 from biodegradable microspheres in the initial release phase characterized by pore diffusion.

257 citations

Journal Article
TL;DR: The results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer level and physico-chemical nature of drug.
Abstract: Purpose: The present study was under- taken to investigate the effect of plastic, hydrophilic and hydrophobic types of polymers and their content level on the release profile of drug from matrix systems. As the physico-chemical nature of the active ingredients influence the drug retarding ability of these polymers, three different drugs were used to evaluate their comparative release char- acteristics in similar matrices. Methods: Matrix tablets of theophylline, diclofenac sodium and diltiazem HCl using Kollidon SR, Carnauba wax and Hydroxypropyl methylcel- lulose (HPMC-15cps) were prepared separately by direct compression process. The USP Basket method was selected to perform the dissolution test carried out in 250 ml 0.1N HCl for first two hours and 1000 ml phosphate buffer of pH 6.8 for ten hours. Results: Statistically signif- icant differences were found among the drug release pro- file from different classes of polymeric matrices. The release kinetics was found to be governed by the type and content of polymer in the matrix system. Higher polymeric content (75%) in the matrix decreased the release rate of drug because of increased tortuosity and decreased poros- ity. At lower polymeric level (25%), the rate and extent of drug release was elevated. Carnauba wax was found to cause the strongest retardation of drug. On the otherhand, highest drug release was from HPMC matrices while Kolli- don SR gave an intermediate release profile between these two polymers. Release rate was also found to be the func- tion of physico-chemical nature of drug molecule. Theo- phylline and diltiazem HCl, being soluble in nature, released faster than diclofenac sodium from all matrix sys- tems. The release mechanism was explored and explained with biexponential equation. Release profile showed a ten- dency to follow zero-order kinetics from HPMC matrix systems whereas Fickian (Case I) transport was predomi- nant mechanism of drug release from Kollidon SR matrix system. The mean dissolution time (MDT) was calculated for all the formulations and the highest MDT value was obtained with Carnauba wax for all the drugs under inves- tigation. Conclusions: The results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer level and physico- chemical nature of drug. A controlled plasma level profile of drug can be obtained by judicious combination of poly- mers and modulation of polymer content in the matrix system.

257 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202366
2022180
2021645
2020815
2019788
2018960