Topic
Drug carrier
About: Drug carrier is a research topic. Over the lifetime, 18276 publications have been published within this topic receiving 997718 citations. The topic is also known as: drug carriers & drug vehicle.
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TL;DR: Polymeric micelles are nanotechnology-based carrier systems that might exert the activity of potent bioactive compounds in a site-directed manner, ensuring their effectiveness and safety in the clinical use.
973 citations
TL;DR: A summary of the achievements in the field to date of non-ionic surfactant vesicles (niosomes) as immunological adjuvants, anti-cancer/anti-infective drug targeting agents and carriers of anti-inflammatory drugs is presented.
958 citations
TL;DR: It is demonstrated that large drug and dye molecules can be encapsulated in zeolitic imidazolate framework (ZIF) crystals, and it is shown that ZIF-8 crystals loaded with the anticancer drug doxorubicin (DOX) are efficient drug delivery vehicles in cancer therapy using pH-responsive release.
Abstract: Many medical and chemical applications require target molecules to be delivered in a controlled manner at precise locations. Metal-organic frameworks (MOFs) have high porosity, large surface area, and tunable functionality and are promising carriers for such purposes. Current approaches for incorporating target molecules are based on multistep postfunctionalization. Here, we report a novel approach that combines MOF synthesis and molecule encapsulation in a one-pot process. We demonstrate that large drug and dye molecules can be encapsulated in zeolitic imidazolate framework (ZIF) crystals. The molecules are homogeneously distributed within the crystals, and their loadings can be tuned. We show that ZIF-8 crystals loaded with the anticancer drug doxorubicin (DOX) are efficient drug delivery vehicles in cancer therapy using pH-responsive release. Their efficacy on breast cancer cell lines is higher than that of free DOX. Our one-pot process opens new possibilities to construct multifunctional delivery systems for a wide range of applications.
947 citations
TL;DR: An update of drug delivery using poly(ethylene glycol) (PEG), that focuses on recent developments in both protein and organic drugs, is presented, that includes applications of high molecular weight PEG prodrug strategies to amino containing drugs.
939 citations
TL;DR: Recent advances in the development of physical stimuli-responsive micelles with high targeting potentials and controlled on-demand drug release are reviewed.
936 citations