Topic
Drug carrier
About: Drug carrier is a research topic. Over the lifetime, 18276 publications have been published within this topic receiving 997718 citations. The topic is also known as: drug carriers & drug vehicle.
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TL;DR: Polymeric micelles based on amphiphilic block copolymers of poly(2-ethyl-2-oxazoline) (PEtOz) and poly(e-caprolactone) (PCL) were prepared in an aqueous phase and exhibited comparable activity to that observed with Cremophore EL-based paclitaxel formulations in inhibiting the growth of KB cells.
238 citations
01 Jan 2005
TL;DR: In this paper, the performance of proniosome gel formulations for the delivery of hydrophobic and hydrophilic drugs was investigated using Franz diffusion cells, and the results showed that the prepared proniosomes significantly improved drug permeation and reduced the lag time.
Abstract: Niosomes are nonionic surfactant vesicles that have potential applications in the delivery of hydrophobic and hydrophilic drugs Permeation of a potent nonsteroidal anti-inflammatory, ketorolac, across excised rabbit skin from various proniosome gel formulations was investigated using Franz diffusion cells Each of the prepared proniosomes significantly improved drug permeation and reduced the lag time (P!005) Proniosomes prepared with Span 60 provided a higher ketorolac flux across the skin than did those prepared with Tween 20 (7- and 4-fold the control, respectively) A change in the cholesterol content did not affect the efficiency of the proniosomes, and the reduction in the lecithin content did not significantly decrease the flux (PO005) The encapsulation efficiency and size of niosomal vesicles formed by proniosome hydration were also characterized by specific high performance liquid chromatography method and scanning electron microscopy Each of the prepared niosomes achieved about 99% drug encapsulation Vesicle size was markedly dependent on the composition of the proniosomal formulations Proniosomes may be a promising carrier for ketorolac and other drugs, especially due to their simple production and facile up q 2004 Elsevier BV All rights reserved
238 citations
TL;DR: In vivo measurements of pharmacokinetics and bioavailability demonstrated higher rates of fenofibrate absorption from both SPC/SDC and SPC/, indicating that liposomes containing bile salts may be used to enhance oral bioavailability of poorly water-soluble drugs.
238 citations
TL;DR: It is demonstrated that the brain concentration of intravenously injected tacrine can be enhanced by binding to poly(n-butylcyanoacrylate) nanoparticles, coated with 1% the nonionic surfactant polysorbate 80.
238 citations
TL;DR: In this paper, a coprecipitation method was used to obtain a biphasic and sustained profile of LMWH anion release with ∼20% in the first 12 hours and another 20% after 108 hours.
Abstract: Magnesium-aluminum-chloride-layered double hydroxides (MgAl-Cl-LDHs) intercalated with low molecular weight heparin (LMWH) were prepared for the first time by the coprecipitation method and then characterized by XRD, elemental analysis, FTIR, SEM, and TEM. MgAl-LDH was studied as the drug carrier for LMWH, a widely used anticoagulant, in order to overcome some of its pharmaceutical limitations, such as its short half-life. In vitro release tests of LMWH-LDH in pH 7.4 PBS at 37 °C show a biphasic and sustained profile of LMWH anion release with ∼20% in the first 12 h and another ∼20% in the following 108 h. After release, the residue was characterized and dissolution−diffusion kinetic models fitted. The mechanism of MgAl-LMWH-LDH release is probably due to surface diffusion and bulk diffusion via anionic exchange of LMWH anions on or in the LDH with anions in the PBS solution.
238 citations