Topic
Drug carrier
About: Drug carrier is a research topic. Over the lifetime, 18276 publications have been published within this topic receiving 997718 citations. The topic is also known as: drug carriers & drug vehicle.
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TL;DR: In this article, various methods of synthesizing polycondensation and ring-opening polymerization and modifying properties of polylactic acid (PLA), which may be used as biomaterials, such as a drug carrier in a drug delivery system, as a cell scaffold and suture in tissue engineering, and as packaging materials in packaging engineering field.
Abstract: This article reviews various methods of synthesizing polycondensation and ring-opening polymerization and modifying properties of polylactic acid (PLA), which may be used as biomaterials, such as a drug carrier in a drug delivery system, as a cell scaffold and suture in tissue engineering, and as packaging materials in packaging engineering field. Copolymerization of lactide with other monomers or polymers such as malic acid, polyethylene glycol (PEG), polyglycolic acid (PGA), or dextran, as well as blending polylactide with natural derivatives and other methods of modification are discussed. Surface modifications of PLA-type copolymers, such as surface coating, chemical modification, and plasma treatment are described.
236 citations
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TL;DR: The comparative study conducted on methotrexate (MTX)-bearing SLNs revealed that the formulation based on Compritol 888 ATO could noticeably improve the oral bioavailability of MTX, presumably following SLNs constituting lipid digestion and co-absorption through lymphatic transport and route.
236 citations
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TL;DR: The results indicate that the surface composition of colloidal drug carriers affects their biodistribution in the eye and this surface modification approach can be used as a targeting strategy in ocular drug delivery.
236 citations
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TL;DR: The π-π stacking interaction between DOX and GO resulted in higher loading capacity and controlled release of the DOX loaded from CMC/GO nanocomposites hydrogel, and interaction between GO and DOX with H-bonding could be unstable under acidic conditions which resulted in faster drug release rate in pH 6.8.
236 citations
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TL;DR: It is found that poly(ethylene glycol)-block-poly(d,l lactic acid) (PEG-b-PLA) micelles can deliver multiple poorly water-soluble drugs at clinically relevant doses.
236 citations