Topic
Drug carrier
About: Drug carrier is a research topic. Over the lifetime, 18276 publications have been published within this topic receiving 997718 citations. The topic is also known as: drug carriers & drug vehicle.
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TL;DR: Although acetazolamide release rates from Eudragit RS microspheres were very slow and incomplete for all formulations, they were fast from EUDragit RL microsphere formulations.
235 citations
TL;DR: A review of the advantages of liposomal delivery systems in general and the divergent approaches that have been taken in developing these agents can be found in this article, where the authors present STEALTH, a novel liposome system coated with polyethylene glycol, avoiding uptake by the reticuloendothelial system, thus improving drug delivery to the tumor.
235 citations
TL;DR: In vitro release of Dox and the degradation of the polymer chain by cathepsin B as well as preliminary evaluation of in vivo anti-cancer activity of the conjugate are demonstrated.
234 citations
TL;DR: Only the most modern self-optimizing aggregates with the ultraflexible membranes (transfersomes) are able to deliver drugs reproducibly either into or through the skin, depending on the choice of administration or application, with a very high efficacy.
234 citations
TL;DR: A recent review of mesoporous silica nanoparticles (MSNs) for drug delivery can be found in this article, where the authors provide an overview of synthesis strategies for fabricating ordered MSNs and hollow/rattle-type MSNs.
Abstract: In the past decade, mesoporous silica nanoparticles (MSNs) have attracted more and more attention for their potential biomedical applications. With their tailored mesoporous structure and high surface area, MSNs as drug delivery systems (DDSs) show significant advantages over traditional drug nanocarriers. In this review, we overview the recent progress in the synthesis of MSNs for drug delivery applications. First, we provide an overview of synthesis strategies for fabricating ordered MSNs and hollow/rattle-type MSNs. Then, the in vitro and in vivo biocompatibility and biotranslocation of MSNs are discussed in relation to their chemophysical properties including particle size, surface properties, shape, and structure. The review also highlights the significant achievements in drug delivery using mesoporous silica nanoparticles and their multifunctional counterparts as drug carriers. In particular, the biological barriers for nano-based targeted cancer therapy and MSN-based targeting strategies are discussed. We conclude with our personal perspectives on the directions in which future work in this field might be focused.
234 citations