Topic
Drug carrier
About: Drug carrier is a research topic. Over the lifetime, 18276 publications have been published within this topic receiving 997718 citations. The topic is also known as: drug carriers & drug vehicle.
Papers published on a yearly basis
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TL;DR: A novel, liposome-based SN-38 formulation, LE-SN38 has shown promising results in terms of increased cytotoxicity against various tumor cell lines and better therapeutic efficacy towards xenograft mouse models compared to CPT-11.
222 citations
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TL;DR: Various temperature, pH, and ion induced in situ-forming polymeric systems used to achieve prolonged contact time of drugs with the cornea and increase their bioavailability are reviewed.
222 citations
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TL;DR: A wide range of orotransmucosal routes being potentially useful for transmucosal drug delivery are overviewed to remind us of the success achieved with these systems and the latest advancement in the field.
221 citations
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TL;DR: A controlled drug release system was designed based on the combination of three advantages into one entity, which was composed of Fe3O4 magnetic nanoparticle as the core, mesoporous silica as the sandwiched layer, and thermo-sensitive P(NIPAM-co-NHMA) copolymer as the outer shell as mentioned in this paper.
Abstract: A controlled drug release system was designed based on the combination of three advantages into one entity, which was composed of Fe3O4 magnetic nanoparticle as the core, mesoporous silica as the sandwiched layer, and thermo-sensitive P(NIPAM-co-NHMA) copolymer as the outer shell The hydrophilic comonomer content affected the volume phase-transition temperature (VPTT) of this composite microsphere and the behavior of the temperature-triggered drug release Zn(II) phthalocyanine tetrasulfonic acid (ZnPcS4), a well-known photodynamic therapy (PDT) drug, was used as a model drug to assess the release system The results demonstrated that the drug release behavior was dependent on the temperature and had a close correlation with the VPTT Above the VPTT, the drug release rate was much faster than that below the VPTT, which showed a great potential application in tumor therapy
221 citations
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TL;DR: The in vivo antitumor activity results showed that DOX-CSO-SA micelles treatments effectively suppressed the tumor growth and reduced the toxicity against animal body than commercial doxorubicin hydrochloride injection.
221 citations