Topic
Drug carrier
About: Drug carrier is a research topic. Over the lifetime, 18276 publications have been published within this topic receiving 997718 citations. The topic is also known as: drug carriers & drug vehicle.
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TL;DR: This study indicates that certain grades of EVA were applicable feedstock material for 3D printing to produce drug-loaded implantable prototypes with the drug incorporated within the entire matrix of the medical devices.
212 citations
TL;DR: In this article, the authors developed pH-sensitive interpenetrating polymeric network (IPN) microgels (MGs) based on chitosan, acrylamide-grafted-poly(vinyl alcohol) and hydrolyzed acryl-glutaraldehyde grafted polymer (GGP) that are crosslinked with glutaraldehyde and used in the controlled release of cefadroxil, an antibiotic drug.
212 citations
TL;DR: A drug carrier carrying a drug is introduced to a diseased region of the living body while it is observed in the B mode echograms and irradiated with an ultrasonic wave for releasing the drug from the drug carrier for curing the diseased portion.
Abstract: A drug carrier carrying a drug is introduced to a diseased region of the living body while it is observed in the B mode echograms. The drug carrier is irradiated with an ultrasonic wave for strongly vibrating the drug carrier, thereby releasing the drug from the drug carrier for curing the diseased portion.
212 citations
TL;DR: The optimized production parameters previously established for drug-free SLN dispersions can therefore be transferred to drug-loaded systems to facilitate product development.
Abstract: Solid lipid nanoparticles (SLN) are a colloidal carrier system for controlled drug delivery. The lipophilic model drugs tetracaine and etomidate were incorporated to study the maximum drug loading, entrapment efficacy, effect of drug incorporation on SLN size, zeta potential (charge) and long-term physical stability. Drug loads of up to 10% could be achieved whilst simultaneously maintaining a physically stable nanoparticle dispersion. Incorporation of drugs showed no or little effect on particle size and zeta potential compared to drug-free SLN. The optimized production parameters previously established for drug-free SLN dispersions can therefore be transferred to drug-loaded systems to facilitate product development.
212 citations
TL;DR: In vivo evaluation indicated the combined solutions had better ability to retain drug than poloxamer analogs or carbopol alone, and it appears that ocular bioavailability can be increased more readily by using the in situ gelling and mucoadhesive vehicle.
212 citations