Topic
Drug carrier
About: Drug carrier is a research topic. Over the lifetime, 18276 publications have been published within this topic receiving 997718 citations. The topic is also known as: drug carriers & drug vehicle.
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TL;DR: This work represents the first successful demonstration of plasmid DNA incorporation into a polymer scaffold using electrospinning, and when tested under tensile loads, the electrospun polymer/DNA composite scaffolds exhibited tensile moduli values that approximate those of skin and cartilage.
793 citations
TL;DR: The novel developments described here may revise the classical outlook that NPs are passive delivery vehicles, in favor of responsive, sensing vehicles that use environmental cues to achieve maximal drug potency.
Abstract: First-generation nanoparticles (NPs) have been clinically translated as pharmaceutical drug delivery carriers for their ability to improve on drug tolerability, circulation half-life, and efficacy. Toward the development of the next-generation NPs, researchers have designed novel multifunctional platforms for sustained release, molecular targeting, and environmental responsiveness. This review focuses on environmentally responsive mechanisms used in NP designs, and highlights the use of pH-responsive NPs in drug delivery. Different organs, tissues, and subcellular compartments, as well as their pathophysiological states, can be characterized by their pH levels and gradients. When exposed to these pH stimuli, pH-responsive NPs respond with physicochemical changes to their material structure and surface characteristics. These include swelling, dissociating or surface charge switching, in a manner that favors drug release at the target site over surrounding tissues. The novel developments described here may ...
793 citations
TL;DR: This review focuses on recent development of the preparation and application for drug delivery of the block copolymer hydrogels that respond to temperature, pH or both stimuli, including poly(N-substituted acrylamide)-based blockcopolymers, poloxamers and their derivatives, poly(ethylene glycol)-polyester block copolemers, polyelectrolyte-based blockCopolymers and the polyelectrodynamic-modified thermo-sensitive block
792 citations
TL;DR: Experimental data show that sustained release of growth factor from the gelatin hydrogels is very effective in exerting the biological functions of the growth factor.
787 citations
TL;DR: arget and sustained drug delivery decreases the drug related toxicity and increase patient’s compliance with less frequent dosing, also providing advancement in diagnostic testing.
Abstract: The development of nanoparticle-based drug formulations has yielded the opportunities to address and treat challenging diseases. Nanoparticles vary in size but are generally ranging from 100 to 500 nm. Through the manipulation of size, surface characteristics and material used, the nanoparticles can be developed into smart systems, encasing therapeutic and imaging agents as well as bearing stealth property. Further, these systems can deliver drug to specific tissues and provide controlled release therapy. This targeted and sustained drug delivery decreases the drug related toxicity and increase patient’s compliance with less frequent dosing. Nanotechnology has proven beneficial in the treatment of cancer, AIDS and many other disease, also providing advancement in diagnostic testing.
781 citations