Topic
Drug carrier
About: Drug carrier is a research topic. Over the lifetime, 18276 publications have been published within this topic receiving 997718 citations. The topic is also known as: drug carriers & drug vehicle.
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TL;DR: Recent advances of Ps as drug delivery systems are discussed, and preparative methods and characterization techniques for Ps, protein and cell interactions with Ps, in vivo circulation kinetics and biodistribution are addressed.
609 citations
TL;DR: Novel applications of Pluronic block copolymers in the treatment of drug-resistant tumors are described as well as mechanistic studies and clinical evaluations of these systems are in progress.
605 citations
TL;DR: A new hyaluronic acid (HA)-based hydrogel film was prepared and evaluated for use in drug delivery and can be employed for controlled release of therapeutic agents at wound sites.
603 citations
TL;DR: The current synthetic advances in polymer-conjugation with different bioactive components of clinical importance are discussed and the strategies for reduction of steric hindrance and increase in reactivity of the polymers, drugs and bioactive agents are described.
599 citations
TL;DR: In this article, a review of lipid nanoparticles based on solid matrix has been conducted to improve the oral bioavailability of several drugs, especially lipophilic compounds, and the stability of the formulations might increase than other liquid nano-carriers due to the solid matrix.
Abstract: Lipid nanoparticles based on solid matrix have emerged as potential drug carriers to improve gastrointestinal (GI) absorption and oral bioavailability of several drugs, especially lipophilic compounds. These formulations may also be used for sustained drug release. Solid lipid nanoparticle (SLN) and the newer generation lipid nanoparticle, nanostructured lipid carrier (NLC), have been studied for their capability as oral drug carriers. Biodegradable, biocompatible, and physiological lipids are generally used to prepare these nanoparticles. Hence, toxicity problems related with the polymeric nanoparticles can be minimized. Furthermore, stability of the formulations might increase than other liquid nano-carriers due to the solid matrix of these lipid nanoparticles. These nanoparticles can be produced by different formulation techniques. Scaling up of the production process from lab scale to industrial scale can be easily achieved. Reasonably high drug encapsulation efficiency of the nanoparticles was documented. Oral absorption and bioavailability of several drugs were improved after oral administration of the drug-loaded SLNs or NLCs. In this review, pros and cons, different formulation and characterization techniques, drug incorporation models, GI absorption and oral bioavailability enhancement mechanisms, stability and storage condition of the formulations, and recent advances in oral delivery of the lipid nanoparticles based on solid matrix will be discussed.
595 citations