Topic
Drug carrier
About: Drug carrier is a research topic. Over the lifetime, 18276 publications have been published within this topic receiving 997718 citations. The topic is also known as: drug carriers & drug vehicle.
Papers published on a yearly basis
Papers
More filters
TL;DR: The effect of size on therapeutic activity (antitumor efficacy and toxicity) of a liposomal anticancer preparation is discussed and the importance of liposome size in the design of a more effective Liposomal antitumor Preparation is discussed.
378 citations
TL;DR: It is demonstrated that a wide variety of water soluble and insoluble bioactive agents can be incorporated into PLGA nanoparticles with a high efficiency and adjustable drug loadings and show great potential in intravascular local drug delivery.
377 citations
TL;DR: The cell membrane-camouflaged nanoparticle platform has emerged as a novel delivery strategy with the potential to improve the therapeutic efficacy for the treatment of a variety of diseases.
377 citations
Journal Article•
TL;DR: Strategies used for formulation of peptides and proteins, methods used for assessment of association efficiency and practical considerations regarding the toxicological concerns are described.
Abstract: This paper highlights the importance of lipid-based colloidal carriers and their pharmaceutical implications in the delivery of peptides and proteins for oral and parenteral administration. There are several examples of biomacromolecules used nowadays in the therapeutics, which are promising candidates to be delivered by means of liposomes and lipid nanoparticles, such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). Several production procedures can be applied to achieve a high association efficiency between the bioactives and the carrier, depending on the physicochemical properties of both, as well as on the production procedure applied. Generally, this can lead to improved bioavailability, or in case of oral administration a more consistent temporal profile of absorption from the gastrointestinal tract. Advantages and drawbacks of such colloidal carriers are also pointed out. This article describes strategies used for formulation of peptides and proteins, methods used for assessment of association efficiency and practical considerations regarding the toxicological concerns.
376 citations
TL;DR: A critique of the literature, the own work, and various simulations suggests that drug release from cyclodextrin complexes is rapid and quantitative in most cases.
375 citations