Topic
Drug carrier
About: Drug carrier is a research topic. Over the lifetime, 18276 publications have been published within this topic receiving 997718 citations. The topic is also known as: drug carriers & drug vehicle.
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TL;DR: It is shown that a strong magnetic field gradient at the tumour location accumulates the nanoparticles and electron microscope investigations show that the ferrofluids can be enriched in tumour tissue and tumour cells.
Abstract: Magnetic drug targeting employing nanoparticles as carriers is a promising cancer treatment avoiding side effects of conventional chemotherapy. We used iron oxide nanoparticles covered by starch derivatives with phosphate groups which bound mitoxantrone as chemotherapeutikum. In this letter we show that a strong magnetic field gradient at the tumour location accumulates the nanoparticles. Electron microscope investigations show that the ferrofluids can be enriched in tumour tissue and tumour cells.
348 citations
TL;DR: The mechanism of modified drug release has been interpreted on the basis of the ion exchange process of the ibuprofen anion intercalated in the lamellar host and phosphates contained in the intestinal fluid buffer.
348 citations
TL;DR: This article examines the current misunderstandings and the main difficulties in targeted drug delivery.
348 citations
TL;DR: In this article, a new approach to prepare surface-functionalized magnetic nanoparticles by synthesis of poly(methacrylic acid) was proposed, and PMAA was applied to magnetically targeted drug carriers by adsorbing an anti-cancer drug.
Abstract: A new approach to prepare surface-functionalized magnetic nanoparticles by synthesis of poly(methacrylic acid)
(PMAA) coated maghemite nanoparticles in aqueous solution is reported. Maghemite (γ-Fe2O3) nanoparticles with an average diameter of 8 ± 2 nm were fabricated and subsequently coated with PMAA by emulsion polymerization. The FTIR study and thermal analysis confirmed the chemical adsorption of methacrylic acid on the maghemite nanoparticle surface, and suggested a symmetrical carboxylate bonding. The free carboxyl group of PMAA, which was verified by FTIR spectroscopy and zeta potential measurement, provided the site for immobilization of foreign molecules. The PMAA coated maghemite nanoparticles were demonstrated as potential magnetically targeted drug carriers by adsorbing an anti-cancer drug (carboplatin)
via the ion–dipole interaction between CO2− of PMAA and carboplatin.
348 citations
TL;DR: The results reveal that the multifunctional hydroxyapatites exhibit the typical ordered characteristics of the hexagonal mesostructure, and have rod-like morphology with the particle size of 20-40 nm in width and 100-200 nm in length.
348 citations