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Drug delivery

About: Drug delivery is a(n) research topic. Over the lifetime, 49772 publication(s) have been published within this topic receiving 1814267 citation(s).

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Journal ArticleDOI: 10.1038/NMAT3776
01 Nov 2013-Nature Materials
Abstract: Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible. Implementation of such devices requires the use of biocompatible materials that are susceptible to a specific physical incitement or that, in response to a specific stimulus, undergo a protonation, a hydrolytic cleavage or a (supra)molecular conformational change. In this Review, we discuss recent advances in the design of nanoscale stimuli-responsive systems that are able to control drug biodistribution in response to specific stimuli, either exogenous (variations in temperature, magnetic field, ultrasound intensity, light or electric pulses) or endogenous (changes in pH, enzyme concentration or redox gradients).

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Topics: Nanocarriers (55%), Drug delivery (55%), Drug carrier (54%)

4,033 Citations


Journal ArticleDOI: 10.1016/S0169-409X(01)00203-4
Yong Qiu1, Kinam Park1Institutions (1)
Abstract: Environmentally sensitive hydrogels have enormous potential in various applications. Some environmental variables, such as low pH and elevated temperatures, are found in the body. For this reason, either pH-sensitive and/or temperature-sensitive hydrogels can be used for site-specific controlled drug delivery. Hydrogels that are responsive to specific molecules, such as glucose or antigens, can be used as biosensors as well as drug delivery systems. Light-sensitive, pressure-responsive and electro-sensitive hydrogels also have the potential to be used in drug delivery and bioseparation. While the concepts of these environment-sensitive hydrogels are sound, the practical applications require significant improvements in the hydrogel properties. The most significant weakness of all these external stimuli-sensitive hydrogels is that their response time is too slow. Thus, fast-acting hydrogels are necessary, and the easiest way of achieving that goal is to make thinner and smaller hydrogels. This usually makes the hydrogel systems too fragile and they do not have mechanical strength necessary in many applications. Environmentally sensitive hydrogels for drug delivery applications also require biocompatibility. Synthesis of new polymers and crosslinkers with more biocompatibility and better biodegradability would be essential for successful applications. Development of environmentally sensitive hydrogels with such properties is a formidable challenge. If the achievements of the past can be extrapolated into the future, however, it is highly likely that responsive hydrogels with a wide array of desirable properties can be made.

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Topics: Self-healing hydrogels (65%), Drug delivery (51%)

3,991 Citations


Journal ArticleDOI: 10.1126/SCIENCE.1095833
Theresa M. Allen1, Pieter R. Cullis2Institutions (2)
19 Mar 2004-Science
Abstract: Drug delivery systems (DDS) such as lipid- or polymer-based nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs administered parenterally. Many of the early problems that hindered the clinical applications of particulate DDS have been overcome, with several DDS formulations of anticancer and antifungal drugs now approved for clinical use. Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics.

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Topics: Drug delivery (51%)

3,861 Citations


Journal ArticleDOI: 10.1016/S0169-409X(00)00124-1
Abstract: Recently, colloidal carrier systems have been receiving much attention in the field of drug targeting because of their high loading capacity for drugs as well as their unique disposition characteristics in the body. This paper highlights the utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core-shell typed colloidal carriers for drug and gene targeting. The process of micellization in aqueous milieu is described in detail based on differences in the driving force of core segregation, including hydrophobic interaction, electrostatic interaction, metal complexation, and hydrogen bonding of constituent block copolymers. The segregated core embedded in the hydrophilic palisade is shown to function as a reservoir for genes, enzymes, and a variety of drugs with diverse characteristics. Functionalization of the outer surface of the polymeric micelle to modify its physicochemical and biological properties is reviewed from the standpoint of designing micellar carrier systems for receptor-mediated drug delivery. Further, the distribution of polymeric micelles is described to demonstrate their long-circulating characteristics and significant tumor accumulation, emphasizing their promising utility in tumor-targeting therapy. As an important perspective on carrier systems based on polymeric micelles, their feasibility as non-viral gene vectors is also summarized in this review article.

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Topics: Micelle (55%), Targeted drug delivery (53%), Drug delivery (52%)

3,298 Citations


Journal ArticleDOI: 10.1016/S0168-3659(00)00339-4
Abstract: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems. Methods of preparation, drug loading and drug release are covered. The most important findings on surface modification methods as well as surface characterization are covered from 1990 through mid-2000.

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Topics: Drug carrier (60%), Drug delivery (59%), Targeted drug delivery (58%)

3,075 Citations


Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2022109
20214,076
20204,226
20193,869
20183,637
20173,694

Top Attributes

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Topic's top 5 most impactful authors

Robert Langer

163 papers, 35K citations

Vladimir P. Torchilin

70 papers, 11.2K citations

Kinam Park

52 papers, 10.3K citations

Hélder A. Santos

51 papers, 2.2K citations

Xuesi Chen

50 papers, 2.5K citations

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