Topic
Dysarthria
About: Dysarthria is a research topic. Over the lifetime, 2402 publications have been published within this topic receiving 56554 citations.
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TL;DR: A substantial number of patients remained on IL–IL because of subjective improvements in gait/balance, speech, or PD symptoms, and a prospective, double-blind, crossover study with objective/quantitative outcome measures is underway.
Abstract: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) using high-frequency (130–185 Hz) stimulation (HFS) is more effective for appendicular than for axial symptoms. Low-frequency stimulation (LFS) of the STN may reduce gait/balance and speech impairment but can result in worsened appendicular symptoms, limiting its clinical usefulness. A novel dual-frequency paradigm (interleave–interlink, IL–IL) was created in order to reduce gait/balance and speech impairment while maintaining appendicular symptom control in Parkinson’s disease (PD) patients chronically stimulated with DBS. Two overlapping LFS programs are applied to each DBS lead, with the overlapping area focused around the optimal electrode contact. As a result, this area receives HFS, controlling appendicular symptoms. The non-overlapping area receives LFS, potentially reducing gait/balance and speech impairment. Patients were separated into three categories based on their chief complaint(s): gait/balance impairment, speech impairment, and/or incomplete PD symptom control. The Clinical- Global Impression of Change scale (CGI-C) was completed retrospectively based on patient/caregiver feedback in patients who remained on IL–IL (at 3 months and at the last follow-up). Seventy-six patients were switched from optimized HFS to IL–IL. Fifty-five (72%) patients remained on IL–IL after 22 ± 8.7 months. The median (range) CGI-C for gait was 2 (1–5) at 3 months and 3 (1–4) at last follow-up, for dysarthria it was 4 (1–4) at 3 months and 4 (1–5) at last follow-up, and for PD motor it was 2 (1–3) at 3 months and 2 (1–3) at last follow-up. A substantial number of patients remained on IL–IL because of subjective improvements in gait/balance, speech, or PD symptoms. A prospective, double-blind, crossover study with objective/quantitative outcome measures is underway.
11 citations
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20 Feb 2011TL;DR: The potential of the simple Bayes rule to reveal changes in degradable speech performance in the course of PD-related dysarthria is presented and its feasibility for identifying the features of the impaired voice is confirmed.
Abstract: This paper presents an assessment of vocal impairment for separating healthy persons from patients with Parkinson's disease (PD). We have recently shown that deterioration of speech performances in PD speakers is notable from an early stage of the disease, even before starting pharmacotherapy. In this study, we present the potential of the simple Bayes rule to reveal changes in degradable speech performance in the course of PD-related dysarthria. The various speech data were recorded from 23 speakers with recently diagnosed PD and 23 healthy speakers. It has been found that 19 various acoustic measurements are able to differentiate PD significantly from healthy speakers. Subsequently, the Bayes theorem was applied to each of these measurements. As a result, the 21 PD patients and 21 healthy people were correctly classified according to their group. The Bayes theorem thus confirms its feasibility for identifying the features of the impaired voice.
11 citations
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TL;DR: Considering phonetic complexity for dysarthria tests could result in more sensitive assessments for detecting and monitoring Dysarthria progression, and less sensitive to mild dysarthrias compared to speech intelligibility for the proposed complexity-based approach.
Abstract: Purpose This study describes a phonetic complexity-based approach for speech intelligibility and articulatory precision testing using preliminary data from talkers with amyotrophic lateral sclerosi
11 citations
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26 Jul 1990
TL;DR: The effects of CNS prophylaxis on speech and language function in children acquired childhood speech disorders dysarthria and dyspraxia are studied.
Abstract: Acquired childhood aphasia - neuro-pathology, linguistic characteristics and diagnosis assessment and treatment of acquired childhood aphasia speech and language disorders following childhood closed head injury communicative disorders in childhood infectious diseases linguistic status following acute cerebral anoxia in children linguistic problems associated with childhood metabolic disorders communicative impairments in neural tube disorders speech and language disorders in childhood brain tumours effect of CNS prophylaxis on speech and language function in children acquired childhood speech disorders dysarthria and dyspraxia
11 citations
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TL;DR: Speech in ET patients without DBS can be impaired, dependent on patient's individual characteristics, and the PSA can be considered an alternative DBS target in ET without higher risk of dysarthria.
11 citations