scispace - formally typeset
Search or ask a question
Topic

Dysarthria

About: Dysarthria is a research topic. Over the lifetime, 2402 publications have been published within this topic receiving 56554 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: New clinical features of delayed motor development, hypotonia, and ataxia in two young children with mutations in the ATP1A3 gene are reported, which are the earliest presentations of RDP, both with fluctuating features.
Abstract: We report new clinical features of delayed motor development, hypotonia, and ataxia in two young children with mutations (R756H and D923N) in the ATP1A3 gene. In adults, mutations in ATP1A3 cause rapid-onset dystonia-Parkinsonism (RDP, DYT12) with abrupt onset of fixed dystonia. The parents and children were examined and videotaped, and samples were collected for mutation analysis. Case 1 presented with fluctuating spells of hypotonia, dysphagia, mutism, dystonia, and ataxia at 9 months. After three episodes of hypotonia, she developed ataxia, inability to speak or swallow, and eventual seizures. Case 2 presented with hypotonia at 14 months and pre-existing motor delay. At age 4 years, he had episodic slurred speech, followed by ataxia, drooling, and dysarthria. He remains mute. Both children had ATP1A3 gene mutations. To our knowledge, these are the earliest presentations of RDP, both with fluctuating features. Both children were initially misdiagnosed. RDP should be considered in children with discoordinated gait, and speech and swallowing difficulties.

82 citations

Journal ArticleDOI
TL;DR: Standard clinical measurement of intelligibility using orthographic transcription may be more consistent than the use of more subjective percent estimates, which are often based on subjective estimates of what speakers with dysarthria think.
Abstract: Many speakers with dysarthria have reduced intelligibility[,] and improving intelligibility is often a primary intervention objective. Consequently, measurement of intelligibility provides important i

81 citations

Journal ArticleDOI
TL;DR: Deep brain stimulation has been reported to be successful in relieving the core motor symptoms of Parkinson's disease and motor fluctuations in the more advanced stages of the disease, but data on the effects of DBS on speech performance are inconsistent.
Abstract: Deep brain stimulation (DBS) has been reported to be successful in relieving the core motor symptoms of Parkinson's disease (PD) and motor fluctuations in the more advanced stages of the disease. However, data on the effects of DBS on speech performance are inconsistent. While there are some series of patients documenting that speech function was relatively unaffected by DBS of the nucleus subthalamicus (STN), other investigators reported on improvements of distinct parameters of oral control and voice. Though, these ameliorations of single speech modalities were not always accompanied by an improvement of overall speech intelligibility. On the other hand, there are also indications for an induction of dysarthria as an adverse effect of STN-DBS occurring at least in some patients with PD. Since a deterioration of speech function has more often been observed under high stimulation amplitudes, this phenomenon has been ascribed to a spread of current-to-adjacent pathways which might also be the reason for the sporadic observation of an onset of dysarthria under DBS of other basal ganglia targets (e.g., globus pallidus internus/GPi or thalamus/Vim). The aim of this paper is to review and evaluate reports in the literature on the effects of DBS on speech function in PD.

81 citations

Journal ArticleDOI
TL;DR: Findings suggested a differential benefit of slowing speech rate to improve intelligibility contingent upon severity of speech deficits.
Abstract: Metronome, singing, and board pacing were used as external rate control techniques for the purpose of comparing the effectiveness of auditory and visual speech timing cues for reducing speech rate and increasing intelligibility in three traumatically brain injured mixed spastic-ataxic dysarthric speakers. A single system design with baseline reversal (ABACAD) was used in this preliminary investigation. Results demonstrated statistically significant (p < 0.05) changes in increased speech intelligibility during all three pacing conditions for the two more involved subjects. Differences between treatment conditions were not statistically significant. However, auditory metronome cuing showed the best results for the two subjects who benefited from rate control. Lower baseline intelligibility was strongly correlated with higher benefit from rate control. Furthermore, the two auditory rhythmic pacing conditions exhibited a close synthronization effect between the frequency rate of the cue and speech rate. Significant correlation coefficients between decreased speech rate and increased intelligibility were only found for the two more involved subjects. These findings suggested a differential benefit of slowing speech rate to improve intelligibility contingent upon severity of speech deficits.

80 citations

Journal ArticleDOI
TL;DR: If intervention targeting breath support, phonation, and speech rate increases speech intelligibility and participation in the conversational interactions of younger children with dysarthria and cerebral palsy is investigated.
Abstract: Aim The aim of this study was to investigate if intervention targeting breath support, phonation, and speech rate increases speech intelligibility and participation in the conversational interactions of younger children with dysarthria and cerebral palsy (CP). Method Fifteen children with dysarthria and CP (nine males, six females; age range 5–11y, mean age 8y, SD 2y; CP type: eight spastic, four dyskinetic, one ataxia, two Worster Drought syndrome; Gross Motor Function Classification System levels II–IV, median level II) participated in this study. Children received three sessions of individual therapy per week for 6 weeks. Intelligibility of single words and connected speech was compared across five points: 1 and 6 weeks before therapy and 1, 6, and 12 weeks after therapy. Three familiar listeners and three unfamiliar listeners scored each recording. Participation in communicative interactions was measured using the Focus on the Outcomes of Communication Under Six (FOCUS) tool. Analyses of variance and paired t-tests were used to investigate change. Results Mean speech intelligibility increased after therapy to familiar listeners (single words 10.8%, 95% confidence interval [CI] 7.2–14.4; connected speech 9.4%, 95% CI 4.8–14.1) and unfamiliar listeners (single words 9.3%, 95% CI 6.8–11.8; connected speech 10.5%, 95% CI 7.3–13.8). FOCUS scores increased following therapy for parents (mean increase 30.3, 95% CI 10.2–50.4) and for teachers (28.25, 95% CI 14.4–42.1), but changes did not correlate with intelligibility. A wide variation was seen in individual responses to therapy. Interpretation Brief intensive therapy is associated with gains in intelligibility and communicative interactions for some younger children with dysarthria.

80 citations


Network Information
Related Topics (5)
Parkinson's disease
27.9K papers, 1.1M citations
82% related
Multiple sclerosis
26.8K papers, 886.7K citations
77% related
White matter
14.8K papers, 782.7K citations
77% related
Cerebellum
16.8K papers, 794K citations
76% related
Traumatic brain injury
25.7K papers, 793.7K citations
76% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023229
2022415
2021164
2020138
2019125
201888